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Author: m miral dizdar
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1. A Major Role for Non-Enzymatic Antioxidant Processes in the Radioresistance of Halobacterium salinarum
M Miral Dizdar, Pawel Jaruga, Courtney K Robinson, Kim Webb, Amardeep Kaur, Nitin S Baliga, Allen Place, Jocelyne DiRuggiero
Oxidative stress occurs when the generation of reactive oxygen species (ROS) exceeds the capacity of the cell‰s endogenous systems to neutralize them. We analyzed the oxidative stress responses and cellular damage of the archaeon Halobacterium salina ...
2. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...
3. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
4. Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound
D. C. Malins, K. M. Anderson, J. J. Stegeman, Pawel Jaruga, V. M. Green, N. K. Gilman, M Miral Dizdar
5. CHEMICAL DETERMINATION OF FREE RADICAL-INDUCED DAMAGE TO DNA
M Miral Dizdar
6. Characterization and Mechanism of Action of Drosophila Ribosomal Protein S3 DNA Glycosylase Activity for the Removal of Oxidatively Damaged DNA Bases
W. A. Deutsch, A. Yacoub, Pawel Jaruga, T. H. Zastawny, M Miral Dizdar
7. Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA
Pawel Jaruga, R Jabil, Amanda K McCullough, H Rodriguez, M Miral Dizdar, R Stephen Lloyd
A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identi ...
8. Copper oxide nanoparticle mediated DNA damage in terrestrial plant models
Bryant C Nelson, Donald H Atha, Elijah J Petersen, Huanhua Wang, Danielle Cleveland, Richard D Holbrook, Pawel Jaruga, M Miral Dizdar, Baoshan Xing
Engineered nanoparticles, due to their unique electrical, mechanical and catalytic properties, are presently found in many commercial products and will be intentionally or inadvertently released at increasing concentrations into the natural environme ...
9. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
10. DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers for atherosclerosis in human urine
M Miral Dizdar, Pawel Jaruga, R Olinski, Rafal Rozalski
Rationale: We hypothesized that oxidatively induced DNA damage products (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) may be well-suited as biomarkers for atherosclerosis in human urine.
Objective: We tes ...