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1. A Major Role for Non-Enzymatic Antioxidant Processes in the Radioresistance of Halobacterium salinarum
M Miral Dizdar, Pawel Jaruga, Courtney K Robinson, Kim Webb, Amardeep Kaur, Nitin S Baliga, Allen Place, Jocelyne DiRuggiero
Oxidative stress occurs when the generation of reactive oxygen species (ROS) exceeds the capacity of the cell‰s endogenous systems to neutralize them. We analyzed the oxidative stress responses and cellular damage of the archaeon Halobacterium salina ...
2. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...
3. Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Erdem Coskun, Pawel Jaruga, Ann-Sofie Jemth, Olga Loseva, Leona Dance Scanlan, Alessandro Tona, Mark S Lowenthal, Thomas Helleday, M Miral Dizdar
MTH1 protein sanitizes the nucleotide pool so that modified 2'-deoxynucleoside triphosphates (dNTPs)
cannot be used in DNA replication. Cancer cells require MTH1 to avoid incorporation of modified
dNTPs resulting in DNA damage mutations and cell ...
4. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
5. Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound
D. C. Malins, K. M. Anderson, J. J. Stegeman, Pawel Jaruga, V. M. Green, N. K. Gilman, M Miral Dizdar
6. Bisphenol A leads to oxidative DNA damage and alters the damage response in mouse fibroblasts
Pawel Jaruga, Natalie R Gassman, Erdem Coskun, Donna F Stefanick, Julie K Horton, M Miral Dizdar, Samuel H Wilson
Metabolism of bisphenol A (BPA) generates reactive oxygen species causing DNA strand breaks and damaged DNA bases. Base excision repair (BER) is responsible for removing oxidatively induced DNA base lesions and for repairing single strand breaks (SSB ...
7. CHEMICAL DETERMINATION OF FREE RADICAL-INDUCED DAMAGE TO DNA
M Miral Dizdar
8. Characterization and Mechanism of Action of Drosophila Ribosomal Protein S3 DNA Glycosylase Activity for the Removal of Oxidatively Damaged DNA Bases
W. A. Deutsch, A. Yacoub, Pawel Jaruga, T. H. Zastawny, M Miral Dizdar
9. Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA
Pawel Jaruga, R Jabil, Amanda K McCullough, H Rodriguez, M Miral Dizdar, R Stephen Lloyd
A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identi ...
10. Clemens von Sonntag and the early history of radiation-induced sugar damage in DNA
M Miral Dizdar
This article reviews the early history of radiation-induced sugar damage in DNA in dedication to Prof. Clemens von Sonntag, who recently passed away. It covers the ten years between 1968 and 1978, during which most of the work on the ionizing radiati ...