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Author: m miral dizdar
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1. Oxidatively Induced Damage to DNA: Potential Role of Single-Wall Carbon Nanotubes at the Molecular Level
Published: 5/13/2013
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. When used to process DNA solutions, these highly reactive hydroxyl radicals can react ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913561

2. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 5/13/2013
Authors: Elijah J Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913562

3. Oxidatively Induced DNA Damage and Cancer
Published: 12/31/2012
Author: M Miral Dizdar
Abstract: Endogenous and exogenous sources cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. Resulting DNA lesions are mutagenic and, unless repaired, lead to a variety of mutations and consequently to genetic instability, wh ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909458

4. Protective roles of single-wall carbon nanotubes in ultrasonication-induced DNA base damage
Published: 8/27/2012
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. Highly reactive hydroxyl radicals can react with DNA to generate strand breaks and a m ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911310

5. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
Published: 7/11/2012
Authors: M Miral Dizdar, Pawel Jaruga, Susan Duclos, Pierre Aller, Susan Wallace, Susan Doublie
Abstract: Formamidopyrimidine-DNA glycosylase (Fpg; MutM) is a DNA repair enzyme widely distributed in bacteria. Fpg recognizes and excises oxidatively modified purines, 4,6-diamino-5-formamidopyrimidine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxogu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911417

6. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 6/20/2012
Authors: Elijah J Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911145

7. Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using 15N-labeled whole proteins as internal standards
Published: 5/30/2012
Authors: M Miral Dizdar, Pawel Jaruga, Prasad T Reddy
Abstract: Oxidatively induced DNA damage is implicated in disease, unless it is repaired by DNA repair. DNA repair proteins may be used as early detection and therapeutic biomarkers in cancer and other diseases. For this purpose, the measurement of the express ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907830

8. Mechanisms of free radical-induced damage to DNA
Published: 4/1/2012
Authors: M Miral Dizdar, Pawel Jaruga
Abstract: Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the heterocyclic DNA bases and the sugar moiety near or at diffusion-controlled ra ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910258

9. DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers for atherosclerosis in human urine
Published: 2/23/2012
Authors: M Miral Dizdar, Pawel Jaruga, R Olinski, Rafal Rozalski
Abstract: Rationale: We hypothesized that oxidatively induced DNA damage products (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) may be well-suited as biomarkers for atherosclerosis in human urine. Objective: We tes ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909816

10. Oxidatively Induced DNA Damage and Cancer
Published: 12/30/2011
Authors: M Miral Dizdar, Pawel Jaruga
Abstract: Oxidatively induced DNA damage is caused by endogenous and exogenous sources in living organisms. Many resulting DNA lesions are mutagenic and lead to mutations commonly found in cancer. Repairs mechanisms exist to repair this type of DNA damage. Unr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908724



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