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Author: m miral dizdar

Displaying records 41 to 50 of 65 records.
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41. Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage
Published: 10/29/2003
Author: M Miral Dizdar
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903147

42. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830363

43. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324

44. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830365

45. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Published: 8/23/2002
Authors: J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830310

46. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
Published: 3/19/2002
Authors: T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
Abstract: 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830581

47. Mass Spectrometric Assays for the Tandem Lesion 8,5'- Cyclo-2' Deoxyguanosine in Mammalian DNA
Published: 3/19/2002
Authors: Pawel Jaruga, M Birincioglu, H Rodriguez, M Miral Dizdar
Abstract: 8,5'-Cyclopurine-2'-deoxynucleosides are among major lesions in DNA that are formed by attack of hydroxyl radical. These compounds represent a concomitant damage to both sugar and base moieties of the same nucleoside and thus can be considered tandem ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830283

48. Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA
Published: 2/1/2002
Authors: Pawel Jaruga, R Jabil, Amanda K McCullough, H Rodriguez, M Miral Dizdar, R Stephen Lloyd
Abstract: A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identi ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830227

49. Determination of Active Site Residues in Escherichia Coli Endonuclease VIII
Published: 1/25/2002
Authors: S. M. Burgess, Pawel Jaruga, M L Dodson, M Miral Dizdar, R Stephen Lloyd
Abstract: Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830285

50. The Cockayne Syndrome Group B Gene Product is Involved in General Genome Base Excision Repair of 8-hydroxyguanine in DNA
Published: 12/7/2001
Authors: J Tuo, M Muftuoglu, C Chen, Pawel Jaruga, R R Selzer, R M Brosh, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne Syndrome (CS) is a human genetic disorder with two complementation groups, CS-A and CS-B. The CSB gene product is involved in transcription-coupled repair of DNA damage but may participate in other pathways of DNA metabolism. The present s ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830260



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