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Author: m miral dizdar

Displaying records 31 to 40 of 59 records.
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31. Repair of Formamidopyrimidines in DNA Involves Different Glycosylases - Role of the OGG1, NTH1, and NEIL1 Enzymes
Published: 12/9/2005
Authors: J Hu, N de Souza-Pinto, K Haraguchi, Barbara A Hogue, Pawel Jaruga, M M Greenberg, M Miral Dizdar, V. Bohr
Abstract: 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA), are formed abundantly in DNA of cultured cells or tissues exposed to ionizing radiation or to other free radical-generating systems. We show here that ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830498

32. Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA
Published: 12/21/2004
Authors: Pawel Jaruga, M Birincioglu, T A Rosenquist, M Miral Dizdar
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903209

33. Oxidative DNA Damage: Induction, Repair and Significance
Published: 9/1/2004
Authors: M D Evans, M Miral Dizdar, M S Cooke
Abstract: The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intra-cellular signaling, and detrimental, modifying cellular bimolecules, accumulation of which has been associated with numerous diseases ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830412

34. Overexpression and Rapid Purification of Escherichia Coli Formamidopyrimidine-DNA Glycosylase
Published: 3/1/2004
Authors: Prasad T Reddy, Pawel Jaruga, T R O'Connor, H Rodriguez, M Miral Dizdar
Abstract: Formamidopyrimidine DNA glycosylase (Fpg) is a DNA glycosylase with an associated AP lyase activity. As a DNA repair enzyme, Fpg excises several modified bases from DNA associated with exposure to oxidizing agents such as free radicals. Experiments ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830402

35. Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage
Published: 10/29/2003
Author: M Miral Dizdar
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903147

36. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830363

37. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324

38. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830365

39. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Published: 8/23/2002
Authors: J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830310

40. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
Published: 3/19/2002
Authors: T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
Abstract: 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830581



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