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Author: m miral dizdar
Displaying records 31 to 40 of 59 records.
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31. Repair of Formamidopyrimidines in DNA Involves Different Glycosylases - Role of the OGG1, NTH1, and NEIL1 Enzymes
J Hu, N de Souza-Pinto, K Haraguchi, Barbara A Hogue, Pawel Jaruga, M M Greenberg, M Miral Dizdar, V. Bohr
2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA), are formed abundantly in DNA of cultured cells or tissues exposed to ionizing radiation or to other free radical-generating systems. We show here that ...
32. Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA
Pawel Jaruga, M Birincioglu, T A Rosenquist, M Miral Dizdar
33. Oxidative DNA Damage: Induction, Repair and Significance
M D Evans, M Miral Dizdar, M S Cooke
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intra-cellular signaling, and detrimental, modifying cellular bimolecules, accumulation of which has been associated with numerous diseases ...
34. Overexpression and Rapid Purification of Escherichia Coli Formamidopyrimidine-DNA Glycosylase
Prasad T Reddy, Pawel Jaruga, T R O'Connor, H Rodriguez, M Miral Dizdar
Formamidopyrimidine DNA glycosylase (Fpg) is a DNA glycosylase with an associated AP lyase activity. As a DNA repair enzyme, Fpg excises several modified bases from DNA associated with exposure to oxidizing agents such as free radicals. Experiments ...
35. Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage
M Miral Dizdar
36. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
37. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
38. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
39. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...
40. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...