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You searched on: Author: m miral dizdar

Displaying records 31 to 40 of 68 records.
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31. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Published: 2/1/2009
Authors: Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Abstract: Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...

32. Measurement of formamidopyrimidines in DNA
Published: 12/15/2008
Authors: Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Abstract: Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...

33. Human Polymorphic Variants of the NEIL1 DNA Glycosylase: Potential Implications for Human Health
Published: 5/25/2007
Authors: Laura Roy, Pawel Jaruga, Thomas Wood, Amanda K McCullough, M Miral Dizdar, R. Stephen Lloyd
Abstract: In mammalian cells, the repair of DNA bases damaged by reactive oxygen species is primarily initiated by a series of DNA glycosylases that include OGG1, NTH1, NEIL1 and NEIL2. To explore the functional significance of NEIL1, we recently reported tha ...

34. Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937
Published: 12/27/2006
Authors: S. G. Nyaga, A. Lohani, Pawel Jaruga, A. Trzeciak, M Miral Dizdar, M. K. Evans

35. Molecular Analysis of Base Damage Clustering Associated with a Site-Specific Radiation-Induced DNA Double-Strand Break
Published: 11/1/2006
Authors: K. Datta, Pawel Jaruga, M Miral Dizdar, R. D. Newmann, T. A. Winters

36. New functions of XPC in the protection of human skin cells from oxidative damage
Published: 9/7/2006
Authors: M. D'Errico, E. Parlanti, M. Teson, B. M. Bernardes de Jesus, P. Degan, A. Calcagnile, Pawel Jaruga, M. Bjoras, M. Crescenzi, A. M. Pedrini, J.-M. Egly, G. Zambruno, M. Stefanini, M Miral Dizdar, E. Dogliotti

37. Oxidative changes in the DNA of stroma and epithelium from the female breast: potential implications for breast cancer
Published: 8/1/2006
Authors: D. C. Malins, K. M. Anderson, Pawel Jaruga, C. R. Ramsey, N. K. Gilman, W. M. Green, S. W. Rostad, J. T. Emerman, M Miral Dizdar

38. Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound
Published: 6/1/2006
Authors: D. C. Malins, K. M. Anderson, J. J. Stegeman, Pawel Jaruga, V. M. Green, N. K. Gilman, M Miral Dizdar

39. Structural alterations in breast stromal and epithelial DNA: the influence of 8,5'-cyclo-2'-deoxyadenosine
Published: 6/1/2006
Authors: K. M. Anderson, Pawel Jaruga, C. R. Ramsey, N. K. Gilman, V. M. Green, S. W. Rostad, J. T. Emerman, M Miral Dizdar, D. C. Malins
Abstract: (5'S)-8,5'-Cyclo-2'-deoxyadenosine (S-cdA), which arises from the reaction of the hydroxyl radical (*OH) with 2'-deoxyadenosine in DNA, is a lesion comprising a base-sugar linkage that distorts the DNA backbone. This structure impedes transcription a ...

40. Repair of Formamidopyrimidines in DNA Involves Different Glycosylases - Role of the OGG1, NTH1, and NEIL1 Enzymes
Published: 12/9/2005
Authors: J Hu, N de Souza-Pinto, K Haraguchi, Barbara A Hogue, Pawel Jaruga, M M Greenberg, M Miral Dizdar, V. Bohr
Abstract: 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA), are formed abundantly in DNA of cultured cells or tissues exposed to ionizing radiation or to other free radical-generating systems. We show here that ...

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