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You searched on: Author: m miral dizdar

Displaying records 11 to 20 of 67 records.
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11. Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 12/26/2012
Authors: M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C Nelson, Gamze Tuna, Prasad T Reddy
Abstract: Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpressio ...

12. Protective roles of single-wall carbon nanotubes in ultrasonication-induced DNA base damage
Published: 8/27/2012
Authors: Elijah J Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C Nelson
Abstract: Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. Highly reactive hydroxyl radicals can react with DNA to generate strand breaks and a m ...

13. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
Published: 7/11/2012
Authors: M Miral Dizdar, Pawel Jaruga, Susan Duclos, Pierre Aller, Susan Wallace, Susan Doublie
Abstract: Formamidopyrimidine-DNA glycosylase (Fpg; MutM) is a DNA repair enzyme widely distributed in bacteria. Fpg recognizes and excises oxidatively modified purines, 4,6-diamino-5-formamidopyrimidine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxogu ...

14. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 6/20/2012
Authors: Elijah J Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...

15. Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using 15N-labeled whole proteins as internal standards
Published: 5/30/2012
Authors: M Miral Dizdar, Prasad T Reddy, Guldal Kirkali, Gamze Tuna, Bryant C Nelson, Pawel Jaruga
Abstract: Oxidatively induced DNA damage is implicated in disease, unless it is repaired by DNA repair. DNA repair proteins may be used as early detection and therapeutic biomarkers in cancer and other diseases. For this purpose, the measurement of the exp ...

16. Mechanisms of free radical-induced damage to DNA
Published: 4/1/2012
Authors: M Miral Dizdar, Pawel Jaruga
Abstract: Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the heterocyclic DNA bases and the sugar moiety near or at diffusion-controlled ra ...

17. DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers for atherosclerosis in human urine
Published: 2/23/2012
Authors: M Miral Dizdar, Pawel Jaruga, R Olinski, Rafal Rozalski
Abstract: Rationale: We hypothesized that oxidatively induced DNA damage products (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) may be well-suited as biomarkers for atherosclerosis in human urine. Objective: We tes ...

18. Oxidatively Induced DNA Damage and Cancer
Published: 12/30/2011
Authors: M Miral Dizdar, Pawel Jaruga
Abstract: Oxidatively induced DNA damage is caused by endogenous and exogenous sources in living organisms. Many resulting DNA lesions are mutagenic and lead to mutations commonly found in cancer. Repairs mechanisms exist to repair this type of DNA damage. Unr ...

19. Copper oxide nanoparticle mediated DNA damage in terrestrial plant models
Published: 12/22/2011
Authors: Bryant C Nelson, Donald H Atha, Elijah J Petersen, Huanhua Wang, Danielle Cleveland, Richard D Holbrook, Pawel Jaruga, M Miral Dizdar, Baoshan Xing
Abstract: Engineered nanoparticles, due to their unique electrical, mechanical and catalytic properties, are presently found in many commercial products and will be intentionally or inadvertently released at increasing concentrations into the natural environme ...

20. Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer
Published: 9/15/2011
Authors: M Miral Dizdar, Pawel Jaruga, Prasad T Reddy, Guldal Kirkali, Didem Keles, Gulgun Oktay, Aras E Canda
Abstract: Molecular pathways that play a role in the development of colorectal cancer involve multiple genetic changes in cancer-related genes that may be caused by overproduction of oxygen-derived species including free radicals, which are capable of damaging ...

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