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Topic Area: Biomaterials

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1. Facile Fabrication of "Dual Click" One- and Two-Dimensional Orthogonal Peptide Concentration Gradients
Topic: Biomaterials
Published: 1/21/2013
Authors: Yanrui Ma, Jukuan Zheng, Emily F. Amond, Christopher M Stafford, Matthew L Becker
Abstract: Peptides, proteins and extracellular matrix act in concert to influence cellular function at the biotic-synthetic interface. However identifying the individual and synergistic contributions of the various combinations and concentration regimes is e ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912748

2. Relative Rigidity of Cell-Substrate Affects Hepatic and Hepatocellular Carcinoma Cell Migration
Topic: Biomaterials
Published: 12/3/2012
Authors: Martin Y Chiang, Hongbing Wang, Li Zhong, Qiaoyan Tan, Gurinder K Singh, Song Li, Li Yang, Yanzi Yangben
Abstract: Polyacrylamide gels with different stiffness and glass were employed as substrates to investigate how substrate stiffness affects the cellular stiffness of adherent hepatocellular carcinoma (HCCLM3) and hepatic (L02) cells. The interaction of how cel ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910699

3. GENERATING CELL CO-CULTURES BY RAPID CELL ADHESION ON OPPOSITE SIDES OF POLYESTER MEMBRANES
Topic: Biomaterials
Published: 10/28/2012
Authors: Conni Hanke, Petra S. Dittrich, Darwin R Reyes-Hernandez
Abstract: A cell co-culture was generated on opposite sides of a permeable polyester membrane (PET) membrane by combining dielectrophoretic (DEP) and electrostatic forces to hold cells against gravity in a multilayer microfluidic device (Figure 1). HepG2 cell ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911771

4. THE ROLE OF TOOTH ENAMEL MECHANICAL PROPERTIES IN PRIMATE DIETARY ADAPTATION
Topic: Biomaterials
Published: 6/27/2012
Authors: Paul Constantino, James J. Lee, Yvonne Beatrice Gerbig, Adam Hartstone-Rose, Mauricio Talebi, Brian Ronald Lawn, Peter Lucas
Abstract: Primate teeth adapt to the physical properties of foods in a variety of ways including changes in occlusal morphology, enamel thickness, and overall size. We conducted a comparative study of extant primates to examine whether their teeth also adap ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907407

5. Optimization of Imaging Polymer Based Scaffolds Using X-Ray Microcomputed Tomography
Topic: Biomaterials
Published: 5/15/2012
Authors: David E, Morris, Melissa L Mather, Carl GEORGE Simon Jr, John A Crowe
Abstract: The performance of polymer based scaffolds used in regenerative medicine is linked to their structural properties and as such strategies for structural characterization of scaffolds have been developed. X-ray microscopic computed tomography (X-ray ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906393

6. Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D
Topic: Biomaterials
Published: 5/1/2012
Authors: Carl GEORGE Simon Jr, Kaushik Chatterjee, Alison McGibbon Kraigsley, Joachim Kohn, Durgadas Bolikal
Abstract: Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematica ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910404

7. Osteoblast Response to Serum Protein Adsorption in 3D Polymer Scaffolds
Topic: Biomaterials
Published: 5/1/2012
Authors: Carl GEORGE Simon Jr, Girish Kumar, Kaushik Chatterjee, Stevephen Hung
Abstract: Protein adsorption is known to direct biological response to biomaterials and is important in determining cellular response in tissue scaffolds. In this study we investigated the effect of adsorbed serum proteins on cell attachment and proliferation ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909572

8. Nano-Apatitic Composite Scaffolds for Stem Cell Delivery and Bone Tissue Engineering
Topic: Biomaterials
Published: 4/15/2012
Authors: Hockin H. K. Xu, Carl GEORGE Simon Jr
Abstract: The need for bone defect repair and regeneration arises from trauma, disease, congenital deformity, and tumor resection. Bone fracture occurs to seven million people each year in the United States, and musculoskeletal conditions cost $215 billion ann ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904167

9. Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape
Topic: Biomaterials
Published: 3/1/2012
Authors: Girish Kumar, Carl GEORGE Simon Jr, Michael S. (Michael Stephan) Waters, Tanya M. Farooque, Marian F Young
Abstract: We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBM ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910664

10. Morphological Changes Driven by Nanofibrous Scaffolds Induce Marrow Stromal Cell Osteogenesis
Topic: Biomaterials
Published: 10/11/2011
Authors: Carl GEORGE Simon Jr, Kaushik Chatterjee, Christopher K. Tison, Girish Kumar, Patrick S Pine, Marc L Salit, Jennifer H McDaniel, Marian F Young
Abstract: Cells are sensitive to tissue scaffold architecture and these cell-material interactions drive cell functions critical in tissue regeneration. Results presented here demonstrate that nanofiber scaffolds force primary human bone marrow stromal cells ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908027