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                      ADVANCED TECHNOLOGY PROGRAM

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        U.S. Department of Commerce + Technology Administration
             National Institute of Standards and Technology
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          Program on INFORMATION INFRASTRUCTURE FOR HEALTHCARE

Healthcare Information Infrastructure Technology Proposal
     South Carolina Research Authority, Columbia, SC (Joint Venture)
     Support the development of a comprehensive open-systems
     architecture for the healthcare industry through four major
     healthcare information infrastructure tasks, tieing the
     results together through a central Open Systems Laboratory
     to provide common R&D services and ensure the
     interoperability of the projects.
     Requested ATP funds: To Be Determined     Est. project budget: TBD
     Announced: October 1994

Methodologies for Automating Clinical Practice Guidelines
     Cerner Corporation, Kansas City, MO
     Develop information tools to automate, validate and
     distribute clinical practice guidelines for mass use.
     Requested ATP funds: $1,984 K            Est. project budget: $3,381 K
     Announced: October 1994

Virtual Computer-Based Patient Record
     First Data Health Systems Corporation, Charlotte, NC (Joint
     Venture)
     Develop an integrated information system that creates a
     "Virtual Computer-based Patient Record" combining
     information from all the original patient record systems in
     a distributed healthcare enterprise.
     Requested ATP funds: $4,854 K            Est. project budget: $9,712 K
     Announced: October 1994

Automated Care Plans and Practice Guidelines
     American Healthware Systems, Brooklyn, NY
     Develop an automated Hospital Care Plan System (HCPS), which
     will issue treatment alerts based on patient-specific
     data -- test results and histories -- and optimal care rules
     encoded in the system.
     Requested ATP funds: $2,000 K            Est. project budget: $3,500 K
     Announced: October 1994

Development of a Seamless Clinical Management System for
Behavioral Health Organizations
     InStream Corporation, Inc., Woburn, MA (Joint Venture)
     Develop a flexible electronic forms system for the
     behavioral health segment of the healthcare industry and
     integrate the system in an easy-to-use, low-cost, accessible
     electronic network.
     Requested ATP funds: $1,370 K            Est. project budget: $2,752 K
     Announced: October 1994

An Expert Knowledge Server With a General Vocabulary Server
Interface
     Applied Medical Informatics, Inc., Salt Lake City, UT
     Develop a powerful medical information system incorporating
     an expert knowledge server that integrates general medical
     knowledge with specific patient information, recovered from
     existing databases, a general model for a "vocabulary
     server," and the framework for an intelligent user
     interface.
     Requested ATP funds: $1,972 K            Est. project budget: $2,628 K
     Announced: October 1994

Voyager: Browsing and Automatically Extracting Healthcare Data
from Scattered Databases
     Belmont Research, Inc., Cambridge, MA
     Develop the tools to enable healthcare providers and
     quality/cost monitors to browse and to extract data
     automatically from a multitude of scattered clinical and
     administrative databases, without requiring changes to the
     existing databases.
     Requested ATP funds: $1,978 K            Est. project budget: $2,581 K
     Announced: October 1994

An Evolvable, Distributed Information Infrastructure for
Interoperation of the Healthcare Delivery System
     Andersen Consulting, Chicago, IL (Joint Venture)
     Develop an open-systems architecture and information
     metastructure to serve as an interface between independent
     healthcare information systems based on a high-level,
     patient-oriented data object.
     Requested ATP funds: $4,339 K            Est. project budget: $8,679 K
     Announced: October 1994

Healthcare Lifetime Data Repository Infrastructure
     3M Company -- Health Information Systems, St. Paul, MN
     Provide key elements in the technology infrastructure that
     will be needed to support integrating the many disparate
     information systems used in the healthcare industry.
     Requested ATP funds: $1,973 K            Est. project budget: $9,086 K
     Announced: October 1994

Development of an Episode Grouper
     3M Company -- Health Information Systems, St. Paul, MN (Joint
     Venture)
     Enable the use of episodes of treatment as a natural and
     logical unit for understanding and controlling healthcare
     resources by defining for the first time episodes of
     treatment for at least 95 percent of the diseases and
     conditions, alone and in combination, found in the enrolled
     population of a typical managed-care organization.
     Requested ATP funds: $1,710 K            Est. project budget: $3,490 K
     Announced: October 1994

Health Informatics Initiative
     C. Everett Koop Institute, Hanover, NH (Joint Venture)
     Analyze the healthcare industry from the point of view of
     modern information management and develop the necessary
     information models and tools to support the task of re-
     engineering the industry to take best advantage of the
     developing National Information Infrastructure.
     Requested ATP funds: $14,741 K          Est. project budget: $30,168 K
     Announced: October 1994

"MEDencode" -- A Technology to Populate a Clinical Data Repository
as a Byproduct of Producing the Clinical Note
     Clinical Information Advantages, Inc., Waltham, MA
     Support improved gathering of clinical information by
     developing tools that facilitate the production of clinical
     notes and, as a byproduct, gather the codified clinical data
     and store it in a database system.
     Requested ATP funds: $2,000 K            Est. project budget: $2,933 K
     Announced: October 1994

Enterprise Tools for the Continuously Available Medical Care
(CAMC) Home Healthcare System
     Intermetrics, Inc., Cambridge, MA
     Develop a "script language" and a related suite of software
     tools to facilitate the process of developing customized
     home healthcare workstations for chronically ill patients.
     Requested ATP funds: $1,803 K            Est. project budget: $2,549 K
     Announced: October 1994

Enterprise Integration Tool Set (EITS) for Healthcare
Professionals
     Unisys Corporation, McLean, VA (Joint Venture)
     Create a "toolset" of software aids that can be used to
     build information brokers -- high-level systems that can
     interact with two or more incompatible healthcare
     information networks, translating and transferring knowledge
     between various data formats and vocabularies.
     Requested ATP funds: $1,407 K            Est. project budget: $2,816 K
     Announced: October 1994

Patient-Oriented Management System (POMS): An Integration
Infrastructure for Health Care
     Benchmarking Partners, Inc., Cambridge, MA
     Develop a reference model that defines the necessary
     communication of administrative and healthcare information
     between domain-specific applications, tools that build
     model-compliant applications, and mechanisms for reviewing
     the model and certifying compliant applications.
     Requested ATP funds: $2,000 K            Est. project budget: $4,872 K
     Announced: October 1994

An Information Infrastructure to Redefine Caregiver Roles: A New
Approach to Integration
     Health Data Sciences Corporation, San Bernardino, CA (Joint Venture)
     Replace current healthcare information systems with an
     integrated system, centered on the patient, and redesign key
     patient-care processes to support more collaborative patient
     care within the framework of the new information system.
     Requested ATP funds: $7,427 K           Est. project budget: $15,146 K
     Announced: October 1994


                  Program on TOOLS FOR DNA DIAGNOSTICS

Compact Blue Laser for Diagnostics
     Uniphase Corp., San Jose, CA (Joint Venture)
     Develop compact, efficient and cheaper source of blue light
     for fluorescence-based diagnostic instruments and techniques
     for physicians and biomedical researchers.
     Requested ATP funds: $1,450 K            Est. project budget: $2,903 K
     Announced: October 1994

Development of Rapid DNA Medical Diagnostics
     GeneTrace Systems, Inc., Menlo Park, CA
     Develop an automated, rapid means for fully determining DNA
     sequency primarily for clinical diagnostics and biomedical
     research applications.
     Requested ATP funds: $1,997 K            Est. project budget: $2,696 K
     Announced: October 1994

Development of a Generic Technology for the Targeted Detection
and Cleavage of DNA and RNA
     Third Wave Technologies, Inc., Madison, WI
     Develop simple-to-use, low-cost, diagnostic tools that
     rapidly detect specific DNA and RNA sequences for broad-
     based medical diagnosis and for tracking treatments.
     Requested ATP funds: $1,998 K            Est. project budget: $2,769 K
     Announced: October 1994

Miniature Integrated Nucleic Acid Diagnostic (MINDtm) Development
     Affymetrix, Inc. & Molecular Dynamics, Inc., Santa Clara, CA
     (Joint Venture)
     Develop a Miniature Integrated Nucleic Acid Diagnostic
     (MINDtm) device, suitable for use in hospitals, clinics or
     doctors' offices, to provide rapid, accurate diagnosis of a
     wide variety of diseases.
     Requested ATP funds: $31,478 K          Est. project budget: $62,965 K
     Announced: October 1994

Molecular Cytogenetics Using the GeneScope: An Ultrafast,
Multicolor System for Automated FISH Analysis
     Bio-Rad Laboratories, Hercules, CA
     Develop an automated clinical instrument, the GeneScope, for
     rapidly characterizing and analyzing cells for genetic type
     or abnormalities.
     Requested ATP funds: $2,000 K            Est. project budget: $3,648 K
     Announced: October 1994

SBH Format 3 Megabase Diagnostics Instrumentation
     Hyseq, Inc., Sunnyvale, CA
     Develop an instrument capable of automatically sequencing as
     many as 100 genes in a single day using libraries of short
     DNA probes that hybridize in overlapping fashion with the
     target DNA to enable full sequencing.
     Requested ATP funds: $2,000 K            Est. project budget: $3,498 K
     Announced: October 1994

DNA Diagnostic Systems Based on Novel Chem-jet Techniques
     Combion, Inc., Redwood City, CA
     Develop a method akin to ink-jet printing for synthesizing
     large arrays of specific DNA fragments suitable for medical
     diagnosis, microbial detection and DNA sequencing, and for
     creating supplies of detachable oligonucleotides for
     subsequent use.
     Requested ATP funds: $1,790 K            Est. project budget: $2,777 K
     Announced: October 1994

Development and Commercial Application of Genosensor Based
Comparative Genome Hybridization
     Vysis, Inc., Naperville, IL
     Develop a "DNA chip" system that can simultaneously quickly,
     reliably, simply and cheaply screen a single biological
     sample for many hundreds of normal and/or abnormal genetic
     features.
     Requested ATP funds: $2,000 K            Est. project budget: $3,514 K
     Announced: October 1994

Integrated Microfabricated DNA Analysis Device for Diagnosis of
Complex Genetic Disorders
     CuraGen Corporation, Bradford, CT (Joint Venture)
     Develop an integrated, modular DNA analysis instrument
     suitable for the efficient diagnosis and treatment of
     complex illnesses, including cardiovascular disease, cancer,
     arthritis, diabetes, and mental illness.
     Requested ATP funds: $2,267 K            Est. project budget: $5,166 K
     Announced: October 1994

MicroLab: A High-Throughput, Low-Cost Approach to DNA Diagnostics
by Array Hybridization
     David Sarnoff Research Center, Princeton, NJ
     Develop a prototype, fully automated DNA "MicroLab," an
     instrument with miniaturized devices capable of assaying
     small, clinical samples of blood for a large selection of
     infectious, non-infectious and genetic diseases.
     Requested ATP funds: $2,000 K            Est. project budget: $8,208 K
     Announced: October 1994

Diagnostic Laser Desorption Mass Spectrometry Detection of
Multiplex Electrophore Tagged DNA
     Bruker Analytical Systems, Inc., Billerica, MA (Joint Venture)
     Develop a powerful DNA sequencing instrument that combines
     electrophoretic separation of multiple target DNA segments
     with specific tags that are rapidly identified with a mass
     spectrometer.
     Requested ATP funds: $3,505 K            Est. project budget: $7,009 K
     Announced: October 1994

Automated DNA Amplification and Fragment Size Analysis
     E.I. du Pont de Nemours & Company (FQMS Group), Wilmington, DE
     Develop an automated, rapid DNA diagnostic system that can
     determine the presence or absence of specific microbial
     contamination as a means of quality control in the food
     industry.
     Requested ATP funds: $2,000 K            Est. project budget: $3,175 K
     Announced: October 1994

Integrated Microfabricated Devices for DNA Typing
     Molecular Tool, Inc., Baltimore, MD
     Scale the company's state-of-the-art Genetic Bit Analysis
     (GBA) technology down by a factor of 1000, developing the
     necessary techniques for micromachining and for handling
     fluids on a microscopic scale to make a simple, compact DNA
     typing instrument.
     Requested ATP funds: $1,962 K            Est. project budget: $2,456 K
     Announced: October 1994


                  Program on COMPONENT-BASED SOFTWARE

Automatic Generation of Mathematical Modeling Components
     SciComp Inc., Austin, TX
     Develop component software and automated software
     composition technologies for the field of scientific
     computing.
     Requested ATP funds: $1,947 K            Est. project budget: $2,235 K
     Announced: October 1994

Cubicon's Visual Programming Environment for Reusable Software
Components
     Cubicon Corporation, Zephyr Cove, NV
     Develop a unique visual programming environment that will
     allow users to construct specific, complex applications from
     reusable software components by selecting, arranging and
     manipulating appropriate components in a three-dimensional
     graphical representation of the application.
     Requested ATP funds: $1,998 K            Est. project budget: $2,430 K
     Announced: October 1994

A Component Technology for Virtual Reality (VR) Based
Applications
     Aesthetic Solutions, Laguna Niguel, CA
     Develop a complete framework for component-based software
     development for powerful virtual-reality applications.
     Requested ATP funds: $1,716 K            Est. project budget: $2,277 K
     Announced: October 1994

Automation of Dependable Software Generation with Reusable
Components
     AT&T Bell Laboratories, Naperville, IL
     Develop an easy-to-use, graphics-oriented software assembly
     system for "non-traditional" programmers that handles the
     complexity of building reliable, custom-designed software by
     using libraries of reusable, domain-specific software
     components.
     Requested ATP funds: $2,000 K            Est. project budget: $5,435 K
     Announced: October 1994

Component Integration: An Architecture-Driven Approach
     Andersen Consulting, Chicago, IL
     Develop a prototype technology for reusable software
     components based on software architecture considerations,
     including formal languages to express semantics, a graphics-
     based programming environment, automated techniques for
     assuring that the separate components are logically
     compatible and properly combined, and automated systems to
     generate executable systems.
     Requested ATP funds: $2,000 K            Est. project budget: $4,012 K
     Announced: October 1994

Component-Based Software System for Parallel Processing Systems
     Applied Parallel Technologies, Inc., Cambridge, MA
     Apply the concepts of component software to simplify and
     speed the development of powerful applications using
     parallel processing.
     Requested ATP funds: $1,983 K            Est. project budget: $2,308 K
     Announced: October 1994

Component-Based Re-engineering Technology
     Reasoning Systems, Inc., Palo Alto, CA
     Use the principles of reusable software components and
     automated software composition to establish the framework to
     easily create customized software re-engineering tools for a
     broad field of "legacy" systems.
     Requested ATP funds: $2,000 K            Est. project budget: $3,433 K
     Announced: October 1994

Scalable Automated Semantic-Based Software Composition
     Kestrel Development Corporation, Palo Alto, CA (Joint Venture)
     Develop a complete suite of software tools based on semantic
     descriptions of software capabilities, and using automated
     deduction, to enable fundamentally new capabilities in
     automated software composition.
     Requested ATP funds: $19,451 K          Est. project budget: $45,655 K
     Announced: October 1994

Scalable Business Application Development Components and Tools
     Continuum Systems, Boxford, MA
     Apply object-oriented technology to provide efficient,
     scalable parallel-computing software and algorithms that can
     be incorporated easily into business applications that are
     hardware-systems independent.
     Requested ATP funds: $2,000 K            Est. project budget: $3,894 K
     Announced: October 1994

Reusable Performance-Critical Software Components Using
Separation of Implementation Issues
     Xerox Corporation -- Palo Alto Research Center, Palo Alto, CA
     Develop a component software technology that separates the
     semantic details of a component from the implementation
     details, to support the use of software components and
     automated software composition for high-performance
     applications.
     Requested ATP funds: $1,785 K            Est. project budget: $3,141 K
     Announced: October 1994

Scalable, Extensible Methods and Tools for Integrating Components
(SEMANTIC)
     Unisys Corporation, Reston, VA (Joint Venture)
     Develop technologies enabling the development of software
     components, distributed software component bases and
     automated system composition tools, emphasizing a layered
     approach that enables system developers to compose
     application systems from components by specifying the
     application needs in domain-specific terms, without
     knowledge of the underlying component complexities.
     Requested ATP funds: $3,522 K            Est. project budget: $7,108 K
     Announced: October 1994


      Program on COMPUTER-INTEGRATED MANUFACTURING FOR ELECTRONICS

A Product-Family-Based Framework for Computer Integrated
Manufacturing
     IBM Corporation, Charlotte, NC
     Create an automation tool suite, enabling commercial
     software vendors to rapidly develop, maintain and join
     families of interoperating products -- sets of manufacturing
     and business applications that work together and can be
     updated in parallel.
     Requested ATP funds: $1,864 K            Est. project budget: $3,160 K
     Announced: October 1994