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Recombinant Proteins in Milk A Bioreactor That Eats Hay


The mammary gland has exceptional capacity for secretion.  To harness this ability, a milk specific promoter is used to direct expression of recombinant proteins into the milk of transgenic animals.  A single transgenic goat can produce over a kg of recombinant protein in a year.  This technology has been successfully utilized to produce recombinant human antithrombin, ATryn, that has been approved for human use by both the US and European regulatory authorities.  Additional human serum proteins and monoclonal antibodies (Mabs) with increased potency are currently in development.


Anyone outside NIST wishing to attend must be sponsored by a NIST employee and receive a visitor badge.

For more information, contact Kum Ham at 301-975-4203.

Colloquia are videotaped and available in the NIST Research Library.


Harry Meade
Senior Vice-President Research and Development
GTC Biotherapeutics, Inc.


Start Date: Friday, March 25, 2011
End Date: Friday, March 25, 2011
Location: 10:30 a.m., Green Auditorium, Gaithersburg, VTC to Boulder in Room 1107
Format: Colloquium