DNA Diagnostics for the
Point of Care Using Electronic Nucleic Acid Detection
Clinical Micro Sensors, Inc., Pasadena, CA
Develop a new approach to DNA diagnostic "chips" that avoids the complex tasks of sample preparation and DNA amplification to produce an inexpensive device for disease screening or on-site testing of food for pathogens.
Requested ATP funds: $1,909 K
Est. project budget: $3,792 K
Announced: October 1998
Liquid Array Technology
Development
Axys Pharmaceuticals, Inc., South San Francisco, CA
Luminex Corporation (Austin, TX)
Develop a complete, customizable approach to building large arrays of liquid-phase DNA probes—up to a million probes in each array cell— capable of doing millions of DNA assays at a time for rapid study of genetic mutations and gene function.
Requested ATP funds: $7,394 K
Est. project budget: $15,090 K
Announced: October 1998
Reference Laboratory
LabChip DNA Diagnostics System
Caliper Technologies Corp., Palo Alto, CA
Develop an integrated system based on microfluidics—the automated handling of microscopic amounts of liquids—to efficiently separate, purify, and analyze DNA samples in nanoliter quantities to enable rapid parallel analysis of hundreds of samples at a time at perhaps a tenth of current costs.
Requested ATP funds: $2,000 K
Est. project budget: $4,147 K
Announced: October 1998
Polymerase Signaling
Assay for DNA Variation Detection on Universal Processor Arrays
Orchid Biocomputer, Inc., Baltimore, MD
Develop novel "universal processor" DNA analysis chip technology based on a standard DNA fragment array and integrated sample preparation and analysis systems to permit very rapid, inexpensive testing for genetic variations for SNP discovery, pharmacogenomics, and medical diagnostics.
Requested ATP funds: $1,954 K
Est. project budget: $2,967 K
Announced: October 1998
Multiplex DNA
Diagnostic Assay Based on Microtransponders
PharmaSeq, Inc., Libertyville, IL
Design and demonstrate a unique low-cost, high-throughput DNA analysis system based on miniaturized, light-activated, reusable microtransponders coupled to DNA probes for DNA diagnostics, pharmaceutical drug discovery, and other applications.
Requested ATP funds: $1,978 K
Est. project budget: $2,518 K
Announced: October 1998
Multiplexed Sample
Preparation Microsystem for DNA Diagnostics
ACLARA BioSciences, Inc., Hayward, CA
Develop technology for inexpensive, miniaturized disposable systems based on microfluidics that integrate DNA sample-preparation tasks—extraction of purified DNA from biosamples and biochemical amplification of the sample—dramatically reducing reagent and labor costs associated with DNA sequencing and genotyping experiments.
Requested ATP funds: $1,999 K
Est. project budget: $3,598 K
Announced: October 1998
Integrated,
Micro-Sample Preparation System for Genetic Analysis
Perkin-Elmer Corp., Applied Biosystems, Foster City, CA
3M BioSystems (St. Paul, MN)
Monsanto (St. Louis, MO)
Millennium Pharmaceuticals, Inc (Cambridge, MA)
Simplify and accelerate the process of DNA sample preparation with an integrated set of microdevices for automated separation and purification of DNA from a wide variety of sources, including bacteria, plant, and mammalian cells, suitable for use with a variety of common analytic procedures.
Requested ATP funds: $9,564 K
Est. project budget: $20,530 K
Announced: October 1998
U.S. Department of Commerce
Technology Administration
National Institute of Standards and Technology
October 1998