Kaushik Chatterjee, Ph.D.

Research Interests

Current work focuses on the development of combinatorial and high-throughput technologies to rapidly screen 3D scaffolds for tissue engineering. We study cell responses (morphology, proliferation and differentiation) of osteoblasts and bone-marrow stromal cells (mesenchymal stem cells) to changes in physical (modulus, porosity, topography, etc.) and bio-chemical (polymer chemistry, peptides, nanoparticles, etc.) properties of 3D hydrogel and plastic scaffold libraries prepared in the form of continuous gradients and discrete arrays. We also investigate biophysical and intracellular signaling pathways in 3D scaffolds to compare and contrast with known mechanisms in 2D culture format.

Background

Towards development of improved hemocompatible biomaterials, for my Ph.D. work at Penn State I studied protein adsorption to material surfaces of blood-plasma proteins involved in the blood coagulation cascade.  For my M.S. research at the University of Virginia my work was focused on investigating crystal structure and phase transformations in metallic and alloy nanoparticles using advanced transmission electron microscopy techniques.

Awards and Recognitions

• NIST MSEL Distinguished Research Associate Award 2010        
• Sigma Xi NIST Chapter Postdoctoral Poster Presentation Second Prize 2009
• National Research Council: NIH/NIST-Joint Postdoctoral Fellowship 2008-10
• American Society for Artificial Internal Organs Student Fellowship 2007
• Penn State Alumni Society Endowed Scholarship Award 2007
• Society for Biomaterials STAR Award 2007
• Penn State Graham Graduate Student Fellowship 2003-04

Membership of Scientific Societies 

• Society for Biomaterials- Elected Secretary/Treasurer for the Proteins and Cells at Interfaces (PCI) Special Interest Group (SIG) 2009-11
• American Chemical Society
• Materials Research Society - MRS Bulletin news reporter

Publications

K. Chatterjee, M.F. Young, C.G. Simon, Jr.: "Fabricating gradient hydrogel scaffolds for 3D cell culture" Combinatorial Chemistry and High Throughput Screening 2011, in press.

S.H. Parekh*, K. Chatterjee* (*equal contribution), S. Lin-Gibson, N.M. Moore, M.T. Cicerone, M.F. Young, C.G. Simon, Jr.: "Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of myosin-based cytoskeletal tension" Biomaterials 2011, in press.

K. Chatterjee, L. Sun, L.C. Chow, M.F. Young, C.G. Simon, Jr.: "Combinatorial screening of osteoblast response to 3D calcium phosphate/ poly(e-caprolactone) scaffolds using gradients and arrays" Biomaterials 2011, 32: 1361-1369.

K. Chatterjee, S. Lin-Gibson, W.E. Wallace, S.H. Parekh, Y.J. Lee, M.T. Cicerone, M.F. Young, C.G. Simon, Jr.: "The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening" Biomaterials 2010, 31: 5051-5062.

C.G. Simon, Y. Yang, S.M. Dorsey, M. Ramalingam, K. Chatterjee: "3D polymer scaffolds" in Biological Micorarrays, Editors- Ali Khadamhosseini, Kahp-Yang Suh and Mohammed Zourab, in Methods in Molecular Biology Series, Vol. 671, Humana Press.K.

Chatterjee, J.L. Thornton, J.W. Bauer, E.A. Vogler, C.A. Siedlecki: "Moderation of prekallikrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition" Biomaterials 2009, 30: 4915-4920.

K. Chatterjee, Z. Guo, E.A. Vogler, C.A. Siedlecki: "Contributions of contact activation pathways of coagulation factor XII in plasma" Journal of Biomedical Materials Research Part A 2009, 90A: 27-34.

K. Chatterjee, E.A. Vogler, C.A. Siedlecki: "Procoagulant activity of surface-immobilized Hageman factor" Biomaterials 2006, 27: 5643-5650.

Z. Guo, K.M. Bussard, K. Chatterjee, R. Miller, E.A. Vogler, C.A. Siedlecki: "Mathematical modeling of material-induced blood plasma coagulation" Biomaterials 2006, 27: 796-806.

J.M. Howe, A.R.S. Gautam, K. Chatterjee, F. Phillipp: "Atomic-level dynamic behavior of a diffuse interface in an Au-Cu alloy" Acta Materialia 2007, 55: 2159-2171.

K. Chatterjee, J.M. Howe, W.C. Johnson, M. Murayama: "Static and in situ TEM investigation of phase relationships, phase dissolution, and interface motion in Ag-Au-Cu alloy nanoparticles" Acta Materialia 2004, 52: 2923-2935.

J.M. Howe, A.M. Mebed, K. Chatterjee, P. Li, M. Murayama, W.C. Johnson: "Effect of phase fraction on the tri-junction in two-phase nanoparticle systems" Acta Materialia 2003, 51: 1359-1372