NIST logo
*
Bookmark and Share

Micronutrients Measurement Quality Assurance Program

Background

Since 1984, the National Institute of Standards and Technology (NIST) has coordinated the Micronutrients Measurement Quality Assurance (QA) Program for laboratories that measure vitamins and carotenoids in human serum and plasma. Interlaboratory comparison studies are currently directed toward the measurement of retinol, gamma-tocopherol, alpha-tocopherol, and beta-carotene. Laboratories also report values for delta-tocopherol, retinyl palmitate, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin, 25-hydroxyvitamin D, coenzyme Q10, vitamin K1, and other related measurands. Frozen or freeze-dried sera are sent to laboratories biannually (winter and spring) for analysis. Results are then returned to NIST for data evaluation and tabulation. Value-assignment of the sample pools is based on the median of all the laboratory results, with confirmation based on measurement at NIST using two or more different methods. Consultation and troubleshooting regarding methods of analysis are also provided. A certificate of participation in the QA program, which displays the laboratory's measurement performance summary for all analytes reported, is issued at the end of each calendar year.

Study Reports

Reports for intercomparisons from 1996 onward are available:

1992
NIST Interagency/Internal Report (NISTIR) 7880-32

1993
NIST Interagency/Internal Report (NISTIR) 7880-31

1994
NIST Interagency/Internal Report (NISTIR) 7880-30

1995
NIST Interagency/Internal Report (NISTIR) 7880-29

1996
NIST Interagency/Internal Report (NISTIR) 7880-28

1997
NIST Interagency/Internal Report (NISTIR) 7880-27

1998
NIST Interagency/Internal Report (NISTIR) 7880-26

1999
NIST Interagency/Internal Report (NISTIR) 7880-25

2000
NIST Interagency/Internal Report (NISTIR) 7880-24

2001
NIST Interagency/Internal Report (NISTIR) 7880-23
NIST Interagency/Internal Report (NISTIR) 7880-22 

2002
NIST Interagency/Internal Report (NISTIR) 7880-21 
NIST Interagency/Internal Report (NISTIR) 7880-20

2003
NIST Interagency/Internal Report (NISTIR) 7880-19
NIST Interagency/Internal Report (NISTIR) 7880-18

2004
NIST Interagency/Internal Report (NISTIR) 7880-17
NIST Interagency/Internal Report (NISTIR) 7880-16

2005
NIST Interagency/Internal Report (NISTIR) 7880-15
NIST Interagency/Internal Report (NISTIR) 7880-14

2006
NIST Interagency/Internal Report (NISTIR) 7880-13
NIST Interagency/Internal Report (NISTIR) 7880-12

2007
NIST Interagency/Internal Report (NISTIR) 7880-11
NIST Interagency/Internal Report (NISTIR) 7880-10

2008
NIST Interagency/Internal Report (NISTIR) 7880-9
NIST Interagency/Internal Report (NISTIR) 7880-8

2009
NIST Interagency/Internal Report (NISTIR) 7880-7
NIST Interagency/Internal Report (NISTIR) 7880-6

2010
NIST Interagency/Internal Report (NISTIR) 7880-5
NIST Interagency/Internal Report (NISTIR) 7880-4

2011
NIST Interagency/Internal Report (NISTIR) 7880-3 
NIST Interagency/Internal Report (NISTIR) 7880-2

2012
NIST Interagency/Internal Report (NISTIR) 7880
NIST Interagency/Internal Report (NISTIR) 7880-1

2013
NIST Interagency/Internal Report (NISTIR) 7880-41
NIST Interagency/Internal Report (NISTIR) 7880-42

Program Costs (for 2014)

 

Exercises Per Year

Annual Participation Fee
(U.S.)

Annual Participation Fee
(non-U.S.)

Fat-Soluble Vitamins and Carotenoids in Serum

2

$1600

$2000


How to Join the Program

If you are interested in joining our program, please download and print the enrollment form (PDF format). You may also obtain more information or enroll by contacting the Micronutrients Measurement Quality Assurance Program at the address shown below.

Micronutrients Measurement Quality Assurance Program
NIST
100 Bureau Dr, Stop 8392
Gaithersburg, MD 20899-8392
Fax:  301-977-0685

Related Standard Reference Materials (SRMs) 968e

srm 968eWe recommend that labs obtain Standard Reference Material (SRM) SRM 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum at the outset of their participation in the QA program to validate their methodology and to value assign in-house control materials. This SRM may be purchased from the Office of Reference Materials at NIST (301-975-2200; fax: 301-948-3730; or e-mail: srminfo@nist.gov).

Related Publications

  1. Brown Thomas, J., Sharpless, K.E., eds., Methods for Analysis of Cancer Chemopreventive Agents in Human Serum; National Institute of Standards and Technology: Gaithersburg, MD, (1995).
  2. Brown Thomas. J., Kline, M.C., Gill, L.M., Yen, J.H., Duewer, D.L., Sniegoski, L.T., Sharpless, K.E., Preparation and Value Assignment of Standard Reference Material 968c Fat-Soluble
    Vitamins, Carotenoids, and Cholesterol in Human Serum
    , Clin. Chim. Acta., 305 (2001), 141-155.
  3. Duewer, D.L., Brown Thomas, J., Kline, M.C., MacCrehan, W.A., Schaffer, R., Sharpless, K.E., May, W.E., NIST/NCI Micronutrients Measurement Quality Assurance Program: Measurement Reproducibility, Repeatability, Stability, and Relative Accuracy for Fat-Soluble Vitamin-Related Compounds in Human Sera, Anal. Chem., 69 (1997), 1406-1416.
  4. Duewer, D.L., Kline, M.C., Sharpless, K.E., Brown Thomas, J.M., Gary, K.T., Sowell, A.L., Micronutrients Measurement Quality Assurance Program: Helping Participants Use Interlaboratory Comparison Exercise Results to Improve their Long-term Measurement Performance, Anal. Chem., 71 (1999) 1870-1878.
  5. Duewer, D.L., Kline, M.C., Sharpless, K.S., Brown Thomas, J., NIST Micronutrients Measurement Quality Assurance Program: Characterizing Individual Participant Measurement Performance Over Time, Anal. Chem., 72(15) (2000), 3611-3619.
  6. Duewer, D.L., Kline, M.C., Sharpless, K.S., Brown Thomas, J., NIST Micronutrients Measurement Quality Assurance Program: Characterizing the Measurement Community's Performance Over Time, Anal. Chem., 72(17) (2000), 4163-4170
  7. Thomas, J.B., Duewer, D.L., Mugenya, I.O., Phinney, K.W., Sander, L.C., Sharpless, K.E., Sniegoski, L.T., Tai, S.S., Welch, M.J., Yen, J.H., Preparation and Value Assignment of Standard Reference Material 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum, Anal. Bioanal. Chem., 402 (2012) 749-762.