Additional Technical Details:
Urine-based SRMs for drugs of abuse were first developed in the late 1980s and early 1990s with materials intended for 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-9-COOH) (the primary marijuana metabolite) (SRM 1507), cotinine (a nicotine metabolite) (RM 8444), cocaine and cocaine metabolite (SRM 1508), morphine and codeine (SRM 2381), and morphine glucuronide (SRM 2382). All the SRMs were certified using multiple analytical methods, primarily isotope dilution GC/MS methods. In 1992 the first hair matrix RMs for drugs of abuse were prepared by soaking hair in dimethylsulfoxide (DMSO) solutions with four target drugs. The two hair RMs were replaced in 2002 by SRM 2379 and 2380 Drugs of Abuse in Hair, which were again prepared by soaking in DMSO with nine drugs (different drugs in each material), but were assigned certified values based on measurements by using ID GC/MS and ID LC/MS. A third matrix for drugs of abuse, serum, will be issued in early 2009 with values for seven drugs, including two (methadone and nordiazepam) that have not been measured in previous matrices.
In recent years the Division has been providing support to DHS in the general area of standards development for chemical measurements primarily in the area of trace explosives detection. The first explosives material issued in 2004, RM 8107 Additives in Smokeless Powder, was developed to help assure the quality of ‘low explosives’ type measurements. The first SRM for high explosives, SRM 2905 Trace Particulate Explosives, was made available in 2009. This explosives reference material and SRMs 2906 and 2907 that followed it are intended for use in calibrating and evaluating the sensitivity and reliability of trace explosive detection equipment.
A beryllium oxide SRM have also been developed in collaboration with DoE and NIOSH to support measurements for assessment of potential aerospace and defense industry worker exposure to beryllium. The Chemical Sciences Division is part of a larger DoD-supported program within MML to provide analytical methods development, quality assurance of measurements, and analysis of high-priority samples to support the mission of this DoD agency.
Lead Organizational Unit:mml
Related Programs and Projects:
Determination of Traces of Fissionable Materials Using Delayed Neutron Activation Analysis
SRM 1511 Multi-Drugs of Abuse in Urine - Benzoylecgonine, morphine, codeine, THC-9-COOH, phencyclidine
SRM 2381 Morphine and Codeine in Urine - Morphine, codeine
RM 8444 Cotinine in Urine - Cotinine
SRM 2285 Arson Test Mixture in Methylene Chloride - Aliphatic hydrocarbons, p-xylene, 2-ethyltoluene, 3-ethyltoluene, 1,2,4-trimethylbenzene
RM 8107 Additives in Smokeless Powder - Nitroglycerin, diphenylamine, N-nitroso-diphenylamine, ethyl centralite
SRM 2905 Trace Particulate Explosive Simulants - TNT, RDX, HMX
SRM 2906 Trace Explosives Calibration Solutions – values assigned for RDX, PETN, TNT
SRM 2907 Trace Terrorist Explosives Simulants - values assigned for TATP, PETN
SRM 1877 Beryllium Oxide Powder - Beryllium