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Inorganic Chemical Metrology

Welcome

The Inorganic Chemical Metrology Group is responsible for developing, critically evaluating, and applying techniques for the identification and measurement of inorganic and organometallic species using X-ray, optical, and mass spectrometries as well as nuclear analytical techniques, classical analytical methods, pH, and electroanalytical methods. Standard Reference Materials (SRMs) and analytical methods development support a variety of industries including advanced materials, cements, ores, and fossil fuels, as well as clinical, food, and environmental analyses. The group develops and maintains primary national standards for elemental and anionic concentrations, pH, electrolytic conductivity, and isotopic abundance.

Programs/Projects

Chemical Metrology for Polymers Manufacturing—Chemical metrology for polymers manufacturing is a new area of endeavor for the Chemical Sciences Division. At the outset, efforts have involved mostly elemental analysis of important virgin …

Standard Reference Materials for Hexavalent Chromium in Contaminated Soil— Significant environmental remediation efforts are being conducted to address the hazards posed by the long-term terrestrial disposal of hexavalent chromium in the form of chromite ore processing …

Support of Industry Compliance with the EU Directive on Restriction of Certain Hazardous Substances (RoHS)— The Chemical Sciences Division is involved in development of standards and reference materials for restricted hazardous substances through participation in international test method development …

Measurements and Standards for Contaminants in Environmental Samples— For the past 40 years NIST has developed SRMs for the determination of inorganic and organic contaminants in environmental matrices such as sediments/soils, marine and animal tissues, air …

Measurement Methods and Standards for Public Safety and Security— Measurements and standards research within the Chemical Sciences Division related to public safety and security include a diverse group of activities that are driven primarily by the needs of …

Simultaneous Determination of Mercury and Tin Species in Standard Reference Materials— Methods applicable to the extraction and quantification of mercury and tin species in biological, environmental, and clinical reference materials using speciated isotope dilution gas …

Certification of Three Soil SRMs for Inorganic Environmental Measurements— Analysis of soils for metals and other elements is essential in assessing environmental compliance and the impacts of potentially toxic elements on human, animal, and plant health. In 1991, NIST …

Interlaboratory Comparison Exercises for Organic Contaminants and Trace Elements in Marine Sediments and Tissues— Three separate interlaboratory comparison exercises for environmental contaminants in marine specimens were administered in 2007/2008 by the Chemical Sciences Division. The oldest program is the …

Metallomics: A Multidisciplinary Approach for the Qualitative and Quantitative Determination of Proteins and Metalloproteins Used as Health and Disease Markers— As healthcare shifts from management of disease to management of health, there will be a necessary shift toward development of quantitative health information. This will require a parallel …

Development of SRM 955c Lead in Caprine Blood— Environmental and occupational exposure to toxic metals is assessed through whole blood analysis. Due to advances in measurement technology, clinical laboratories that perform whole blood analyses …

Development of Measurements and Standards for Biofuels— With concerns over the limited supply of non-renewable forms of energy, there is growing interest in renewable sources of energy such as biofuels. The change to renewable energy, however, presents …

Nanoparticle Characterization— The Chemical Sciences Division is helping to support nanotechnology research being conducted throughout NIST by developing and applying methods for the chemical compositional characterization of …

Advanced Materials Characterization— The Chemical Sciences Division supports the characterization of new, diverse, and technological critical materials. The constant evolution of material science and technology challenge existing …

Chemical Characterization of Nanoparticles— The Chemical Sciences Division is helping to support nanotechnology research being conducted throughout NIST by developing and applying methods for the chemical compositional characterization of …

CCQM Activities in the Inorganic Analysis Working Group and the Electrochemical Analysis Working Group— NIST maintains an active role in these two CCQM working groups, participating in international key comparisons and pilot studies, organizing new studies, and working with other national metrology …

International Comparisons— Because of NIST's role as the National Metrology Institute (NMI) in the U.S., the Chemical Sciences Division's measurement capabilities must be benchmarked against the capabilities of NMIs …

Fusion Wall Development Research by Neutron Depth Profiling— In an inertial fusion energy (IFE) reactor, the plasma-facing surface of the chamber, the first wall, is subjected to high doses of light ions and high temperatures produced by 2H + 3H ? 4He + n …

Measurements, Standards, and Reference Materials for Industrial Commodities— All industrial sectors rely on elemental analysis and physical properties testing to confirm product compliance with manufacturing specifications. Support of product compliance testing has long …

Support of the Consumer Products Safety Improvement Act (CPSIA) of 2008 – Lead in Paint on Toys— After enactment of the CPSIA, a collaboration was established between the Consumer Product Safety Commission (CPSC) and NIST for the purpose of developing tools for the validation of test methods …

A New SRM for Better Beryllium Safety— Beryllium exposure poses a significant health risk, and a new SRM has been developed to enhance beryllium safety in the workplace. SRM 1877 Beryllium Oxide Powder consists of high-fired, …

Determination of Traces of Fissionable Materials Using Delayed Neutron Activation Analysis— Detecting clandestine fissile material like 235U and 239Pu is technically challenging in the lab or in the field because it emits little radiation, and that radiation is energetically weak. …

Renewal of NIST Benchmark SRMs for Accurate Determinations of Trace Elements in Serum and Liver Tissues— The Centers for Disease Control and Prevention (CDC) collects data on elemental composition of human body fluids and tissues as part of major studies such as the National Health and Nutrition …

Development of SRMs for Accurate Assessment of Exposure to Toxic Elements and Anions— As part of a multi-year interagency agreement between the National Institute of Standards and Technology (NIST) and Centers for Disease Control and Prevention (CDC), NIST is developing Standard …

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure— The National Institute of Standards and Technology (NIST), in collaboration with the Centers for Disease Control and Prevention (CDC), has developed Standard Reference Material (SRM) 2669 Arsenic …

Measurements and Standards for Contaminants in Biological (Human) Materials— For the past 25 years NIST has developed a number of biological fluid and tissue Standard Reference Materials (SRMs) primarily for clinically important analytes (e.g., cholesterol, glucose, …

Optimization of the Standard Addition Method (SAM) Using— The standard addition method (SAM) was first described by oceanographers in 1955 to overcome matrix effects in the determination of strontium in seawater. SAM is a core Inorganic Chemical …

Standard Solution SRMs Provide Traceability for Millions of Measurements— For decades, NIST has provided the SRM 3100 series single-element standard solutions. The certified values are traceable to the International System of Units (SI), enabling users to establish …

NIST SRM for Reproducible Analyses of Single-Walled Carbon Nanotubes— Carbon nanotubes (CNTs) are one of the first major nanoscale manufactured products to enter the market. Therefore, reliable and reproducible quantitative measurement and characterization of CNT …

Determinations of Boron Deposit Quality by Neutron Depth Profiling— Straw detectors are a new concept in position-sensitive neutron detectors recently developed by Proportion Technology Inc. The detectors are especially valuable in large-area imaging applications …

Development of Reference Methods and Reference Materials for Proteins — A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example, measurement of the protein cardiac troponin …

Chemical Metrology for Metals, Ores, and Related Materials— A wide range of industrial sectors and their customers and suppliers are involved directly with NIST in the prioritization and development of certified reference materials, and in the development …

High-Precision Isotopic Reference Materials— Recent innovative advances in the design and manufacture of isotope ratio mass spectrometers (IRMS) have revolutionized the study of natural and man-induced isotopic variations. Currently, none of …

Analytical Metrology in Support of the US Hydrogen Infrastructure— Under the initiative 'Enabling the Hydrogen Economy,' NIST will apply its unique facilities and expertise in the multi-agency effort to make hydrogen fuel an effective economical and safe …

Mercury Vapor Pressure Correlation— An apparent difference between the historical mercury vapor concentration equations used by the mercury atmospheric measurement community and a new vapor pressure correlation proposed by NIST has …

Fossil Fuel Standard Reference Materials— To support regulatory and industry requirements for reference materials and standards, NIST produces and maintains a large inventory of fossil fuel SRMs that are certified for sulfur and other …

Reference Materials and Standards for Fossil Fuels, Electric Utility Emissions, and Coal Combustion By-Products— National Institute of Standards and Technology (NIST) fossil fuel Standard Reference Materials (SRMs) continue to be in high demand by the petroleum industry and the fossil fuel-based electric …

Activated Carbon and FGD Gypsum Standard Reference Materials— New Standard Reference Materials (SRMs) consisting of activated carbon sorbent materials and flue gas desulfurization (FGD) gypsum are being developed to support specific mercury measurement needs …

Continuing Support for Cement Manufacturing— Cement manufacturers and their customers rely on the NIST Portland cement SRMs for laboratory qualification under ASTM International C 114-07 Standard Test Methods for Chemical Analysis of …

New Gold Nanoparticle RMs Support Nanotechnology Research— Three new reference materials (RMs) have been developed through a multi-division effort at NIST, led by the MML Ceramics Division. RMs 8011, 8012, and 8013 consist of colloidal suspensions of …

Measurement Quality in Hydrogen Storage R&D— No existing hydrogen storage material satisfies the Department of Energy (DoE) goal of achieving a commercial hydrogen storage system for competitive hydrogen-powered transportation. Accelerating …

Study of Microheterogeneity in Solid Reference Materials— Microbeam X-ray fluorescence (µXRF) has been used nondestructively to investigate elemental heterogeneity by constructing two-dimensional maps of elemental concentrations in reference materials. …

Potential Primary Measurement Tool for the Quantification of DNA—The accurate mass determination of DNA and other nucleic acids is of critical importance in many clinical diagnoses and in forensic and molecular biological studies. In addition, these measurements …

pH Metrology— The pH metrology program supports traceability for pH measurements. This traceability rests on primary pH measurements in an ideal electrochemical cell (Harned cell) and on an internationally …

Neutron Imaging for Health, Environment, and the Hydrogen Economy— Quantitative imaging tools enhance our ability to understand biological systems and achieve efficient hydrogen fuel cells. Today's metrological needs reach beyond existing optical and radiographic …

Improving High-Performance Inductively-Coupled Plasma Optical Emission Spectrometry (HP-ICP-OES) Through Exact Matching— Using high-performance inductively coupled plasma optical emission spectrometry (HP-ICP-OES), relative expanded uncertainties on the order of 0.2 % can be routinely achieved. Nevertheless, …

Evaluation of Independent High-Precision Assay Procedures for a High-Purity Primary Standard Reagent— NIST assigns assay values for a suite of high-purity reagents using two techniques: coulometry and titrimetry. Coulometry is based on Faraday's Laws of Electrolysis (amount of substance is …

Environmental Leaching of Nanoparticles from Consumer Products— Nanoparticle-based consumer products are becoming available in the market at an increasing rate, but the safety of nanoparticles and the environmental fate of nanoparticles derived from consumer …

Chemical Characterization of Nanomaterial Formulations for Cancer Treatment in Support of the NCI Nanotechnology Characterization Laboratory— New generations of nanoparticles are being developed to provide early-stage detection and treatment of cancer. Much of the evaluative work on these systems is being conducted by the Nanotechnology …