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Jane Ladner

Jane Ladner received her Ph.D. in Chemistry from the California Institute of Technology for projects in electron spin resonance and nuclear magnetic resonance. She worked briefly at ICN continuing a project with nmr of t-RNAs. She then had the opportunity to go to the MRC Laboratory in Cambridge, England where she joined Aaron Klug’s group and participated in solving the X-ray structure of Phenalanine t-RNA. At that time a new lab was being set up in Heidleberg by EMBO and she joined the staff there and worked on fiber diffraction. Then she came back across the Atlantic to work with Col. Lipscomb at Harvard where she worked on an X-ray structure of an ACTase complex. The next move brought her to Maryland where she did not seek at position until 1992 when she joined Gary Gilliland at NIST/CARB and first worked on the BMCD (Biological Marcromolecular Crystallization Database). She then got back into the laboratory working on X-ray structures of enzymes. Her interests include the crystallization process and solving macromolecular structures.

Representative Publications

Greenhagen, B. T., Shi, K., Robinson, H., Gamage, S., Bera, A. K., Ladner, J. E., Parsons, J. F. (2008). Crystal Structure of the Pyocyanin Biosynthetic Protein PhzS, Biochemistry 47, 5281-5289.

Thompson, L.C., Ladner, J.E., Codreanu, S.G., Harp, J., Gilliland, G.L., Armstrong, R.N. (2007). 2-Hydroxychromene-2-carboxylic Acid Isomerase: A Kappa Class Glutathione Transferase from Pseudomonas putida, Biochemistry 46, 6710-6722.

Parsons, J.F., Greenhagen, B.T., Shi, K., Calabrese, K., Robinson, H., Ladner, J.E. (2007) Structural and Functional Analysis of the Pyocyanin Biosynthetic Protein PhzM from Pseudomonas aeruginosa, Biochemistry 46,1821-1828.

Jane Ladner

Position:

Research Chemist
Biomolecular Measurement Division
Macromolecular Structure and Function

Employment History:

1971 - 1971 Post-Doctoral Fellow at Nucleic Acid Research Institute, ICN, Riverside, California

1971 - 1976 Staff Member, Medical Research Council Laboratory of Molecular Biology, Cambridge, England

1976 - 1979 Staff Member, European Molecular Biology Laboratory, Heidleberg, Germany

1979 – 1983 Postdoctoral Fellow, Harvard University, Cambridge, MA

1992 - present Research Chemist, National Institute of Standards and Technology

Education:

Ph.D. Chemistry, California Institute of Technology, 1971

B.A. Chemistry, University of California, Santa Barbara, 1966

Contact

Phone: 240-314-6206
Email: jane.ladner@nist.gov
Fax: 240-314-6255