Dr. Rebecca Zangmeister

My research expertise is the characterization of (bio)molecules at surfaces (planar and nanomaterial) with the goal being understanding, controlling and/or improving molecular adhesion and presentation for varied applications. Currently, I am investigating affinity methods for glycan analysis in the context of biomanufacturing of protein drug products. The glycosylation, or sugar decoration patterns, in a protein product can affect the safety and efficacy of that product and requires careful monitoring at various stages in the product development and manufacturing process. Current projects use lectins, or carbohydrate binding proteins, in the development of rapid and robust glycoassays, with an emphasis on the understanding of the binding between lectins and carbohydrates (free or attached to a protein) when one or both is tethered to a sensing element.

Currently, I am serving as the Science Advisor for the Biomolecular Measurement Division at NIST.

NRC Postdoctoral Research Opportunities

Biomolecule Surface Interactions for Diagnostics and Sensing

Metrology Tools for Biomanufacturing

Studies of Bio-Nanomaterials

Recent Publications

Sanchez-Pomales, G.; Morris, T. A.; Falabella, J. B.; Tarlov, M. J.; Zangmeister, R. A., A lectin-based gold nanoparticle assay for probing glycosylation of glycoproteins. Biotechnology and Bioengineering 2012, 109, (9), 2240-2249.

Pond MA, Zangmeister RA "Carbohydrate-Functionalized Surfactant Vesicles for Controlling Glycan Density" Talanta, 2012, 91, 134-139.

Zangmeister, R. A. (2012), "Application of x-ray photoelectron spectroscopic analysis to protein adsorption on materials relevant to biomanufacturing," Journal of Pharmaceutical Sciences. doi: 10.1002/jps.23023

Germarie Sánchez-Pomales and Rebecca A. Zangmeister, "Recent Advances in Electrochemical Glycobiosensing," International Journal of Electrochemistry, vol. 2011, Article ID 825790, 11 pages, 2011. doi:10.4061/2011/825790.

Committees

USP Glycan Expert Panel