Welcome to the NIST Biochemical Science Division Clinical DNA Information Resource

CDIR is a reservoir of information for clinical DNA Standard Reference Materials (SRMs) including presentations, publications, and links to NIST SRM certificates.  Also included are webpages that summarize the purpose for the reference material and the methods used for certification.  CMV project pages contain additional information that researchers and clinicians may find useful. Future materials have progress updates.

General Information

• Publications/Presentations
• Marcia J. Holden et. al. "Molecular diagnostics: harmonization through reference materials,documentary standards and proficiency testing." Expert Rev. Mol. Diagn. 11(7), 741–755 (2011) [pdf] NEW!
  
  

 

Standard Reference Materials (SRMs)

 

Clinical DNA SRMs

• Cytomegalovirus for DNA Measurements (SRM 2366)
  
  • SRM Page (view Certificate or purchase SRM 2366)
  • CMV project pages
• Huntington's Disease (SRM 2393)
  
  • SRM Page (view Certificate or purchase SRM 2393)
  • Huntington's Disease project page
    
• Fragile X Human DNA Triplet Repeat Standard (SRM 2399)
  
  • SRM Page (view Certificate or purchase SRM 2399)

SRMs in Progress

• BK virus
  
  • BK virus project page
    
  
  

Other DNA Based SRMs

• Human DNA Quantitation Standard (SRM 2372)
  
  • SRM Page (view Certificate or purchase SRM 2372)

• Mitochondrial DNA Sequencing (SRM 2392)
  
  • SRM Page (view Certificate or purchase SRM 2392)

• Mitochondrial DNA Sequencing (Human HL-60 DNA) (SRM 2392-I)
  
  • SRM Page (view Certificate or purchase SRM 2392-I)

• PCR-Based DNA Profiling (SRM 2391c)
  
  • View Certificate or purchase SRM 2391c

• Human Y-Chromosome DNA Profiling (SRM 2395)
  
  • View Certificate or purchase SRM 2395

Additional Materials Under Consideration

• Epstein-Barr virus