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Dr. Michael Halter

Michael Halter received his Ph.D. in Bioengineering from the University of Washington at Seattle in 2004. In 2006 he started in the Biochemical Science Division at the National Institute of Standards and Technology (NIST) through a NRC postdoctoral fellowship. After completing his postdoctoral work in 2008, Dr. Halter became a permanent staff scientist at NIST. Since that time, Dr. Halter has worked in the Cell Systems Science group at NIST working with automated microscopy and developing methods to quantify cellular processes using data collected by quantitative imaging and flow cytometry. Dr. Halter has developed imaging assays based on the detection of cellular GFP to measure enzyme activities in large numbers of single cells and ribosome activity after intoxication with ricin. In addition, Dr. Halter has developed a model to interpret cell volume distributions measured during the routine maintenance of cultured cells. Dr. Halter is particularly interested in developing methods that ensure that data collected from cultured cells is quantitative and can be compared across different laboratories.


Interested in a NIST-NRC Postdoctoral Fellowship?
2-year fellowship at NIST in the area of:
Design, development and evaluation of surface plasmon resonance imaging as a quantitative microscopy of live cells and their extracellular environment. Contact Michael Halter if interested in applying and writing a proposal (3000 words).  Application deadlines Feb. 1 and Aug. 1.  Open to U.S. citizens, $65,600 stipend plus benefits, relocation expenses included.


M. Halter, J. L. Almeida, A. Tona, K. D. Cole, A. L. Plant, J. T. Elliott, “A mechanistically relevant cytotoxicity assay based on the detection of cellular GFP.” Assay Drug Dev Technol. 2009 Aug;7(4):356-65.

A. W. Peterson, M. Halter, A. Tona, K. Bhadriraju, and A. L. Plant, “Surface Plasmon Resonance Imaging of Cells and Extracellular Matrix Proteins.” BMC Cell Biology. 2009 Feb; 10(16).

M. Halter, J.T. Elliott, J.B. Hubbard, A. Tona, A. L. Plant, “Cell volume distributions reveal cell growth rates and division times.” J. Theor. Biol. 2009 Mar; 257(1):124-30.

Elliott, J.T., Halter, M., Plant, A.L., Woodward, J.T., Langenbach, K.J., Tona, A., “Evaluating the performance of fibrillar collagen films formed at polystyrene surfaces as cell culture substrates.” Biointerphases. 2008 June; 3(2):19-28.

M. Halter, Y. Liao, D. Coffey, D. Ginger, B. Robinson, and S. Keller, “Molecular Self-Assembly of Mixed High-Beta Zwitterionic and Neutral Ground-State NLO Chromophores.” Chem. of Mater. 2008 Feb; 20(5): 1778-1787.

M. Halter, A. Tona, K. Bhadriraju, A. L. Plant, J. T. Elliott, “Automated live cell imaging of green fluorescent protein degradation in individual fibroblasts.” Cytometry A. 2007 Oct; 71(10): 827-34.

M. Halter*, M. Antia*, and V. Vogel, “Fibronectin conformational changes induced by adsorption to liposomes,” Journal of Controlled Release, 101(1-3), 209-22, (2005).

M. Halter, Y. Nogata, O. Dannenberger, T. Sasaki, and V. Vogel. “Engineered Lipids that Cross-link the Inner and Outer Leaflets of Lipid Bilayers,” Langmuir, 20(6), 2416-2423, (2004).

S. L. McArthur, M. Halter, V. Vogel, D. G. Castner. “Covalent Coupling and Characterization of Supported Lipid Layers,” Langmuir, 19(20), 8316-8324, (2003).

A. Erdemir, M. Halter, G. R. Fenske, C. Zuiker, R. Csencsits, A. R. Krauss, and D. M. Gruen, “Friction and Wear Mechanisms of Smooth Diamond Films During Sliding in Air and Dry Nitrogen,” Tribology Transactions, 40(4), 667-675, (1997).

A. Erdemir, M. Halter, G. R. Fenske, A. R. Krauss, D. M. Gruen, S. M. Pimenov, V. I. Konov, “Durability and Tribological Performance of Smooth Diamond Films Produced by Ar-C60 Microwave Plasmas and By Laser Polishing,” Surface & Coatings Technology Proceedings of the 1997 24th International Conference on Metallurgical Coatings and Thin Films, 94-95(1-3), 537-542, (1997).

A. Erdemir, M. Halter, “Preparation of Ultralow-friction Surface Films on Vanadium Diboride,” Wear, 205(1-2), 236-239, (1997).

Dr. Michael Halter


Research Scientist
Biosystems and Biomaterials Division
Cell Systems Science Group

Employment History:

(2008-present) National Institute for Standards and Technology (NIST), Research Scientist, Cell Systems Science Group

(2006-2008) National Institute for Standards and Technology (NIST), NRC Postdoctoral Research Associate

(2005) University of Washington, Department of Chemistry, Postdoctoral Research Associate

(1998-2004) University of Washington, Department of Bioengineering


Ph.D., Bioengineering, University of Washington, 2004
B.S., Materials Science and Engineering, Purdue University, 1998


Phone: 301-975-4195
Fax: 301-975-8246