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Dr. Arlin Stoltzfus

Arlin Stoltzfus received his Ph.D. in Biology from the University of Iowa for his laboratory studies of natural variation in the E. coli genome. He then converted to computational biology during a post-doctoral fellowship with W. Ford Doolittle (Dalhousie University, Nova Scotia), where he used computer simulations and statistical data analysis to study the evolution of introns.

Since coming to CARB in 1999, Stoltzfus has maintained a computational research program focused on the evolution of introns, the development of software infrastructure to facilitate comparative (evolutionary) analysis, and the evolutionary role of biases in variation. Software projects include the Bio::NEXUS library, the Nexplorer web server, and the Comparative Data Analysis Ontology. Studies on the role of biases in variation have included evolutionary simulations, population-genetics models, and analysis of comparative and experimental data, including the analysis that resulted in the “EX” measure of experimental exchangeability of amino acids in proteins (Yampolsky and Stoltzfus, 2005).

Sample Publications

A. Stoltzfus. 2008. Evidence for a predominant role of oxidative damage in germline mutation in mammals Mutat Res 644:71-73.

T. Hladish, V. Gopalan, C. L. Liang, W. G. Qiu, P. J. Yang, and A. Stoltzfus. 2007. Bio::NEXUS: a Perl API for the NEXUS format for comparative biological data. BMC Bioinformatics 8:191.

A. Stoltzfus. 2006. Mutationism and the Dual Causation of Evolutionary Change. Evolution and Development, 8: 304-317.

V. Gopalan, W.G. Qiu, M.Z. Chen and A. Stoltzfus. 2006. Nexplorer: Phylogenetic browsing and manipulation of sequence family data. Bioinformatics 22(1):120-1.

L.Y. Yampolsky and A. Stoltzfus. 2005. The Exchangeability of Amino Acids in Proteins. Genetics 170, 1459-1472.

W.-G. Qiu, N.J. Schisler and A. Stoltzfus. 2004. Spliceosomal intron gain: sequence and phase preferences. Molecular Biology and Evolution 21:1252-63.

L. Y. Yampolsky and A. Stoltzfus. 2001. Bias in the introduction of variation as an orienting factor in evolution, Evol Dev, 3, 73-83.

A. Stoltzfus. 1999. On the possibility of constructive neutral evolution. J. Mol. Evol. 49(2):169-181.

A. Stoltzfus, J. M. Logsdon, Jr., J. D. Palmer, and W. F. Doolittle. 1997. Intron "sliding" and the diversity of intron positions. Proc. Natl. Acad. Sci. U.S.A. 94: 10739-10744.

A. Stoltzfus, D.F. Spencer, M. Zuker, J.M. Logsdon, Jr.,and W.F. Doolittle. 1994. Testing the exon theory of genes: the evidence from protein structure. Science 265:202-7.

NIST-NRC Postdoctoral Fellowship:

2-year fellowship in computational studies of molecular evolution at NIST (US citizens only). $63,400 salary plus benefits, relocation expenses included. Application deadlines Feb. 1 and Aug. 1. Contact Arlin Stoltzfus if interested in writing proposal (3000 words).


Dr. Arlin Stoltzfus


Research Biologist
Biochemical Science Division
Cell Systems Science Group

Employment History:


  • Research Biologist, National Institute of Standards and Technology
  • Fellow, Center for Advanced Research in Biotechnology (Rockville, MD)
  • Adjunct Assoc. (2006) Professor, University of Maryland Biotechnology Institute


BA, cum laude, English, Grinnell College, 1985
PhD, Biology, University of Iowa, 1991


Phone: 240-314-6208
Email: arlin.stoltzfus@nist.gov
Fax: 240-314-6208