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Sheng Lin-Gibson, Ph.D.

Major Research Programs

Measurement technologies and standards for regenerative and advanced therapies
NIST Laboratory Programs
Documentary Standards
ISO/TC 276: Biotechnology
Reference Materials

Biomaterials 
Dental materials
Virtual Photopolymerization; also see Materials Genomic initiative
Biomaterials Group

 

Standardization for Biotechnology

NIST administers the US TAG to ISO/TC276 Biotechnology as a means to coordinate national and international standards activities for existing and emerging biotechnology sectors. A robust standards infrastructure is critical for biotechnology in the:

       Protection of public health, safety, and the environment
       Development and commercialization of new technologies
      
Facilitation of national and international commerce

 

Research Opportunities

NIST-NRC Postdoctoral Fellowship: 2-year fellowship at NIST sponsored by the National Research Council. Please contact me if interested in developing a proposal.

 

Awards and Honors

  • Department of Commerce Bronze Medal (2014)
  • Research Full Professor, Dean's Faculty position, School of Dentistry, University of Maryland (since 2012)
  • NIST Sigma Xi Young Investigator Award (2011)
  • Department of Commerce Bronze Medal (2010)
  • National Research Council Postdoctoral Research Fellow

 

Publications

  • Chen C, Weir MD, Cheng L, Lin NJ, Lin-Gibson S, Chow LC, Zhou XD, Xu HHK, Antibacterial Activity and Ion Release of Bonding Agent Containing Amorphous Calcium Phosphate Nanoparticles, Dental Materials, 2014, 30(8), 891-901.
  • Wang DB, Ye J, Hudson SD, Scott, KCK, Lin-Gibson S. Effect of Nanoparticles Size and Charge on Interactions with Self-Assembled Collagen. Journal of Colloid and Interface Science, 2014, 417, 244-249. 
  • Waters MS, Kindu S, Lin NJ, Lin-Gibson S, Microstructure and Mechanical Properties of in Situ Streptococcus mutans Biofilms, ACS Applied Materials & Interfaces, 2014, 6(1), 327-332. 
  • Ye J, Wang DB, Zeiger DN, Miles WC, Lin-Gibson S. Different Kinetic Pathways of Early Stage Calcium-Phosphate Cluster Aggregation Induced by Carboxylate-Containing Polymers, Biomacromolecules, 2013, 14(13), 3417-3422. 
  • Zhang K, Cheng L, Imazato S, Antonucci JM, Lin NJ, Lin-Gibson S, Bai YX, Xu HHK. Effects of Dual Antibacterial Agents MDPB and Nano-silver in Primer on Microcosm Biofilm, Cytotoxicity and Dentine Bond Properties. Journal of Dentistry, 2013, 41(5), 464-474.
  • Tutak W, Sarkar S, Lin-Gibson S, Farooque TM, Jyotsnendu G, Wang D, Kohn J, Bolikal D, Simon CG, The Support of Bone Marrow Stromal Cell Differentiation by Airbrushed Nanofiber Scaffold, Biomaterials, 2013, 34(10), 2389-2398. 
  • Kraigsley AM, Tang K, Lippa KA, Howarter JA, Lin-Gibson S, Lin NJ. Effect of Polymer Degree of Conversion on Streptococcus mutans Biofilms. Macromolecular Biosciences, 2012, 12(12), 1706-1713. 
  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Lin NJ, Lin-Gibson S, Xu SM, Zhou XD. Effect of Amorphous Calcium Phosphate and Silver Nanocomposites on Dental Plaque Microcosm Biofilms, J Biomed Mater Res B, 2012, 100B(5), 1378-1386. 
  • Cheng L, Weir MD, Xu HHK, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine. Dental Materials, 2012, in press. 
  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. Dental Materials, 2012, accepted.
  • Lin NJ, Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S. Positively-charged dimethacrylates to reduce bacterial attachment. Biomaterials Forum, 2012, in press.
  • Wear, K.A., Nagaraja, S., Dreher, M.L., Lin-Gibson, S. Relationship of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro, Journal of the Acoustical Society of America, 2012, in press.
  • Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S, Fowler BO, Lin NJ. Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications. Dental Materials, 2012, 28(2): 219-228.
  • Lin, N.J.; Lin-Gibson, S.; Sun, J.; Ding, Y. Effects of Polymeric Nanogratings on Cell Orientation, Biomaterials Forum, 2011
  • Chiang M.Y.M.; Giuseppetti, A.M.; Qian J.; Dunkers J.P.; Antonucci J.M.; Schumacher, G.E.; Lin- Gibson, S. Analyses of a Cantilever-Beam Based Instrument for Evaluating the Development of Polymerization Stresses, Dental Materials, 2011, 27, 899-905.
  • Zeiger, Diana N.; Miles, William C.; Eidelman, Naomi; Lin-Gibson, Sheng, Cooperative Calcium Phosphate Nucleation within Collagen Fibrils, Langmuir, 2011, 27, 8262-8268.
  • Parekh, Sapun H.; Chatterjee, Kaushik; Lin-Gibson, Sheng; Moore, Nicole M.; Cicerone, Marcus T.; Young, Marian F.; Simon, Carl G., Jr.  Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of myosin-based cytoskeletal tension, Biomaterials, 2011, 32, 2256-2264.
  • Cheng, Y.J.; Zeiger, D.N.; Howarter, J.; Zhang, X.; Lin, N.J.; Antonucci, J.M.; Lin-Gibson, S. In situ Formation of Silver Nanoparticles in Photo-cross-linking Polymers. Journal of Biomedical Materials Research: Part B, 2011, 97B, 124-131.
  • Simon, Jr. C.G.; Lin-Gibson, S. Combinatorial and High-Throughput Screening of Biomaterials. Advanced Materials 2011, 23, 369-387.
  • Cheng, Y. J.; Antonucci, J. M.; Hudson, S. D.; Lin, N. J.; Zhang, X. R.; Lin-Gibson, S. Controlled In Situ Nanocavitation in Polymeric Materials. Advanced Materials 2011, 23, 409-413.
  • Ding, Y. F.; Sun, J. R.; Ro, H. W.; Wang, Z.; Zhou, J.; Lin, N. J.; Cicerone, M. T.; Soles, C. L.; Lin-Gibson, S. Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies. Advanced Materials 2011, 23, 421-425.
  • Zeiger, D. N.; Stafford, C. M.; Cheng, Y. J.; Leigh, S. D.; Lin-Gibson, S.; Lin, N. J. Effects of Sample Preparation on Bacterial Colonization of Polymers. Langmuir 2010, 26, 2659-2664.
  • Chatterjee, K.; Lin-Gibson, S.; Wallace, W. E.; Parekh, S. H.; Lee, Y. J.; Cicerone, M. T.; Young, M. F.; Simon, C. G. The Effect of 3D Hydrogel Scaffold Modulus on Osteoblast Differentiation and Mineralization Revealed by Combinatorial Screening. Biomaterials 2010, 31, 5051-5062.
  • Ding, Y. F.; Qi, H. J.; Alvine, K. J.; Ro, H. W.; Ahn, D. U.; Lin-Gibson, S.; Douglas, J. F.; Soles, C. L. Stability and Surface Topography Evolution in Nanoimprinted Polymer Patterns Under a Thermal Gradient. Macromolecules 2010, 43, 8191-8201.
  • Sun, J. R.; Ding, Y. F.; Lin, N. J.; Zhou, J.; Ro, H.; Soles, C. L.; Cicerone, M. T.; Lin-Gibson, S. Exploring Cellular Contact Guidance Using Gradient Nanogratings. Biomacromolecules 2010, 11, 3067-3072.
  • Sun, J.; Eidelman, N.; Lin-Gibson, S. 3D Mapping of Polymerization Shrinkage Using X-Ray Micro-Computed Tomography to Predict Microleakage. Dental Materials 2009, 25, 314-320.
  • Grieshaber, S. E.; Farran, A. J. E.; Lin-Gibson, S.; Kiick, K. L.; Jia, X. Q. Synthesis and Characterization of Elastin-Mimetic Hybrid Polymers With Multiblock, Alternating Molecular Architecture and Elastomeric Properties. Macromolecules 2009, 42, 2532-2541.
  • Dorsey, S. M.; Lin-Gibson, S.; Simon, C. G. X-Ray Microcomputed Tomography for the Measurement of Cell Adhesion and Proliferation in Polymer Scaffolds. Biomaterials 2009, 30, 2967-2974.
  • Lin-Gibson, S.; Sung, L. P.; Forster, A. M.; Hu, H. Q.; Cheng, Y. J.; Lin, N. J. Effects of Filler Type and Content on Mechanical Properties of Photopolymerizable Composites Measured Across Two-Dimensional Combinatorial Arrays. Acta Biomaterialia 2009, 5, 2084-2094.
  • Lin, N. J.; Hu, H. Q.; Sung, L. P.; Lin-Gibson, S. Quantification of Cell Response to Polymeric Composites Using a Two-Dimensional Gradient Platform. Combinatorial Chemistry & High Throughput Screening 2009, 12, 619-625.
  • Alvine, K.J.; Ding Y.F.; Douglas J.F.; Ro H.W.; Okerberg B.C.; Karim A; Lavery K.A.; Lin-Gibson S.; Soles C.L. Effect of Fluorosurfactant on Capillary Instability in Nanoimprinted Polymer Patterns. Journal of Polymer Science Part B- Polymer Physics 2009, 47, 2591-2600.
  • Lin, N. J.; Lin-Gibson, S. Osteoblast Response to Dimethacrylate Composites Varying in Composition, Conversion and Roughness Using a Combinatorial Approach. Biomaterials 2009, 30, 4480-4487.
  • Zeiger, D. N.; Sun, J. R.; Schumacher, G. E.; Lin-Gibson, S. Evaluation of Dental Composite Shrinkage and Leakage in Extracted Teeth Using X-Ray Microcomputed Tomography. Dental Materials 2009, 25, 1213-1220.
  • Jirun, S.; Rui, F.; Lin, N.; Eidelman, N.; Lin-Gibson, S. Nondestructive Quantification of Leakage at the Tooth-Composite Interface and Its Correlation With Material Performance Parameters. Biomaterials 2009, 4457-4462.
  • Sun, J. R.; Lin-Gibson, S. X-Ray Microcomputed Tomography for Measuring Polymerization Shrinkage of Polymeric Dental Composites. Dental Materials 2008, 24, 228-234.
  • Yang, Y. Y.; Dorsey, S. M.; Becker, M. L.; Lin-Gibson, S.; Schumacher, G. E.; Flaim, G. A.; Kohn, J. C.; Simon, C. G. X-Ray Imaging Optimization of 3D Tissue Engineering Scaffolds Via Combinatorial Fabrication Methods. Biomaterials 2008, 29, 1901-1911.
  • Hobbie, E. K.; Lin-Gibson, S.; Kumar, S. Non-Brownian Microrheology of a Fluid-Gel Interface. Physical Review Letters 2008, 100.
  • Morgan, A. W.; Roskov, K. E.; Lin-Gibson, S.; Kaplan, D. L.; Becker, M. L.; Simon, C. G. Characterization and Optimization of RGD-Containing Silk Blends to Support Osteoblastic Differentiation. Biomaterials 2008, 29, 2556-2563.
  • Madsen, E. L.; Frank, G. R.; Hobson, M. A.; Lin-Gibson, S.; Hall, T. J.; Jiang, J.; Stiles, T. A. Instrument for Determining the Complex Shear Modulus of Soft-Tissue-Like Materials From 10 to 300 Hz. Physics in Medicine and Biology 2008, 53, 5313-5342.
  • Cooper, J. A.; Li, W. J.; Bailey, L. O.; Hudson, S. D.; Lin-Gibson, S.; Anseth, K. S.; Tuan, R. S.; Washburn, N. R. Encapsulated Chondrocyte Response in a Pulsatile Flow Bioreactor. Acta Biomaterialia 2007, 3, 13-21.
  • Kashiwagi, T.; Fagan, J.; Douglas, J. F.; Yamamoto, K.; Heckert, A. N.; Leigh, S. D.; Obrzut, J.; Du, F. M.; Lin-Gibson, S.; Mu, M. F.; Winey, K. I.; Haggenmueller, R. Relationship Between Dispersion Metric and Properties of PMMA/SWNT Nanocomposites. Polymer 2007, 48, 4855-4866.
  • Lin, N. J.; Drzal, P. L.; Lin-Gibson, S. Two-Dimensional Gradient Platforms for Rapid Assessment of Dental Polymers: A Chemical, Mechanical and Biological Evaluation. Dental Materials 2007, 23, 1211-1220.
  • Lin-Gibson, S.; Cooper, J. A.; Landis, F. A.; Cicerone, M. T. Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties. Biomacromolecules 2007, 8, 1511-1518.
  • Landis, F. A.; Stephens, J. S.; Cooper, J. A.; Cicerone, M. T.; Lin-Gibson, S. Tissue Engineering Scaffolds Based on Photocured Dimethacrylate Polymers for in Vitro Optical Imaging. Biomacromolecules 2006, 7, 1751-1757.
  • Lin-Gibson, S.; Landis, F. A.; Drzal, P. L. Combinatorial Investigation of the Structure-Properties Characterization of Photopolymerized Dimethacrylate Networks. Biomaterials 2006, 27, 1711-1717.
  • Wilder, E. A.; Guo, S.; Lin-Gibson, S.; Fasolka, M. J.; Stafford, C. M. Measuring the Modulus of Soft Polymer Networks Via a Buckling-Based Metrology. Macromolecules 2006, 39, 4138-4143.
  • Byrd, H. C. M.; Bencherif, S. A.; Bauer, B. J.; Beers, K. L.; Brun, Y.; Lin-Gibson, S.; Sari, N. Examination of the Covalent Cationization Method Using Narrow Polydisperse Polystyrene. Macromolecules 2005, 38, 1564-1572.
  • Dundigalla, A.; Lin-Gibson, S.; Ferreiro, V.; Malwitz, M. M.; Schmidt, G. Unusual Multilayered Structures in Poly(Ethylene Oxide)/Laponite Nanocomposite Films. Macromolecular Rapid Communications 2005, 26, 143-149.
  • Patel, N. P.; Hunt, M. A.; Lin-Gibson, S.; Bencherif, S.; Spontak, R. J. Tunable CO2 Transport Through Mixed Polyether Membranes. Journal of Membrane Science 2005, 251, 51-57.
  • Zhang, K.; Simon, C. G.; Washburn, N. R.; Antonucci, J. M.; Lin-Gibson, S. In Situ Formation of Blends by Photopolymerization of Poly(Ethylene Glycol) Dimethacrylate and Polylactide. Biomacromolecules 2005, 6, 1615-1622.
  • Lin-Gibson, S.; Jones, R. L.; Washburn, N. R.; Horkay, F. Structure-Property Relationships of Photopolymerizable Poly(Ethylene Glycol) Dimethacrylate Hydrogels. Macromolecules 2005, 38, 2897-2902.
  • Caliskan, G.; Mechtani, D.; Roh, J. H.; Kisliuk, A.; Sokolov, A. P.; Azzam, S.; Cicerone, M. T.; Lin-Gibson, S.; Peral, I. Protein and Solvent Dynamics: How Strongly Are They Coupled? Journal of Chemical Physics 2004, 121, 1978-1983.
  • Hobbie, E. K.; Lin-Gibson, S.; Wang, H.; Pathak, J. A.; Kim, H. Ubiquity of Domain Patterns in Sheared Viscoelastic Fluids. Physical Review e 2004, 69.
  • Lin-Gibson, S.; Kim, H.; Schmidt, G.; Han, C. C.; Hobbie, E. K. Shear-Induced Structure in Polymer-Clay Nanocomposite Solutions. Journal of Colloid and Interface Science 2004, 274, 515-525.
  • Lin-Gibson, S.; Bencherif, S.; Cooper, J. A.; Wetzel, S. J.; Antonucci, J. M.; Vogel, B. M.; Horkay, F.; Washburn, N. R. Synthesis and Characterization of PEG Dimethacrylates and Their Hydrogels. Biomacromolecules 2004, 5, 1280-1287.
  • Lin-Gibson, S.; Pathak, J.; Grulke, E.; Wang, H.; Hobbie, E. Elastic Flow Instability in Nanotube Suspensions. Physical Review Letters 2004, vol.92, no.4, 048302-1-048302/4.
  • Lin-Gibson, S.; Pathak, J. A.; Grulke, E. A.; Wang, H.; Hobbie, E. K. Elastic Flow Instability in Nanotube Suspensions. Physical Review Letters 2004, 92.
  • Hobbie, E. K.; Wang, H.; Kim, H.; Lin-Gibson, S.; Grulke, E. A. Orientation of Carbon Nanotubes in a Sheared Polymer Melt. Physics of Fluids 2003, 15, 1196-1202.
  • Lin-Gibson, S.; Walls, H. J.; Kennedy, S. B.; Welsh, E. R. Reaction Kinetics and Gel Properties of Blocked Diisocyinate Crosslinked Chitosan Hydrogels. Carbohydrate Polymers 2003, 54, 193-199.
  • Lin-Gibson, S.; Bencherif, S. A.; Beers, K. L.; Byrd, H. C. M. MALDI-TOF Mass Spectral Characterization of Covalently Cationized Polystyrene. Macromolecules 2003, 36, 4669-4671.
  • Lin-Gibson, S.; Schmidt, G.; Kim, H.; Han, C. C.; Hobbie, E. K. Shear-Induced Mesostructure in Nanoplatelet-Polymer Networks. Journal of Chemical Physics 2003, 119, 8080-8083.
  • Malwitz, M. M.; Lin-Gibson, S.; Hobbie, E. K.; Butler, P. D.; Schmidt, G. Orientation of Platelets in Multilayered Nanocomposite Polymer Films. Journal of Polymer Science Part B-Polymer Physics 2003, 41, 3237-3248.
  • Lin-Gibson, S.; Brunner, L.; Vanderhart, D. L.; Bauer, B. J.; Fanconi, B. M.; Guttman, C. M.; Wallace, W. E. Optimizing the Covalent Cationization Method for the Mass Spectrometry of Polyolefins. Macromolecules 2002, 35, 7149-7156.
  • Lin-Gibson, S.; Baranauskas, V.; Riffle, J. S.; Sorathia, U. Cresol Novolac-Epoxy Networks: Properties and Processability. Polymer 2002, 43, 7389-7398.
  • Lin-Gibson, S.; Glass, T. E.; Shultz, A. R.; Riffle, J. S. Controlled Molecular Weight Cresol-Formaldehyde Oligomers. Polymer 2002, 43, 2017-2029.
Photo of Sheng Lin-Gibson.

Position:

* Leader, Biomaterials Group, Biosystems and Biomaterials Division    * Director, Regenerative Medicine Program                                            * Chair, US TAG to ISO/TC 276, Biotechnology
* Program Director: NIDCR-NIST Interagency Agreement

Education:


Ph.D., Polymer Chemistry, Virginia Tech

B.S., Biochemistry, Virginia Tech

B.A., Chemistry, Virginia Tech

Contact

Phone: 301-975-6765
Email: slgibson@nist.gov
Fax: 301-975-4977