Dynamics of glassy material and its application in protein preservation:
Local and high-frequency motions (on nanosecond timescale and Angstrom length scale) in glassy matrix are critical for stabilizing proteins. Experimental evidences have suggested that a correlation exists between fast dynamics properties of glass matrix and the stability of proteins embedded within the glass matrix. These fast, local dynamics can be measured by dielectric spectroscopy (β relaxation) or by neutron scattering (mean-squared-displacement, MSD). We aim to develop fluorescence methods (Steady State & Time-resolved) for routine measurement of solvation dynamics in picosecond to nanosecond time regime, from which important information including MSD can be determined to support protein stability prediction. Effects of antiplasticization and annealing on glass dynamics and their implication in protein formulation development are investigated. I am also interested in understanding the fundamental properties of glass dynamics with neutron scattering technique.
Awards & Honors
University of Maryland Excellence in Graduate Research Award 2009
1. Marcus T. Cicerone, Qin Zhong, Jerainne Johnson, Khaled A. Aamer, and Madhusudan Tyagi, "Surrogate for Debye-Waller Factors from Dynamic Stokes Shifts," J. Phys. Chem. Let. 2(12), 1464-1468 (2011).
2. Feng Ding, Zhonghan Hu, Qin Zhong, Katherine Manfred, Rafael Gattass, Robert Walker and John T. Fourkas, John weeks and Michael Brindza, "Interfacial Organization of Acetonitrile: Simulation and Experiment," J. Phys. Chem. C 114(41), 17651-17659 (2010).
3. Feng Ding, Qin Zhong, Michael Brindza, Robert Walker and John T. Fourkas, "Ti: Sapphire, Broadband Sum Frequency Generation Spectrometer with a Counter-propagating Geometry," Optics Express 17(17), 14526-14533 (2009)
4. Qin Zhong and John T. Fourkas, "Optical Kerr Effect Spectroscopy of Simple Liquids," J. Phys. Chem. B 112(49), 15529-15539 (2008).
5. Qin Zhong and John T. Fourkas, "Shape and Electrostatic Effects in Optical Kerr Effect Spectroscopy of Aromatic Liquids," J. Phys. Chem. B 112(48), 15342-15348 (2008).
6. Qin Zhong and John T. Fourkas, "Searching for Voids in Liquids with Optical Kerr Effect Spectroscopy," J. Phys. Chem. B 112(29); 8656-8663 (2008).
7. Qin Zhong, Xiang Zhu and John T. Fourkas, "Temperature-Dependent Orientational Dynamics of 1,n-Dicyano n-Alkanes," J. Phys. Chem. B 112 (10), 3115-3120 (2008).
8. Qin Zhong, Xiang Zhu and John T. Fourkas, "Antiresonant-Ring Kerr Spectroscopy," Optics Express 15(11), 6561-6568 (2007).
9. Xiang Zhu, Richard A. Farrer, Qin Zhong and John T. Fourkas, "Orientational Diffusion of n-Alkyl Cyanides," J. Phys. Cond. Matt. 17, 4105-4118 (2005).
Guest Researcher, NIST, Gaithersburg, MD 2009 - present
Ph.D. in Physical Chemistry, University of Maryland, College Park, 2009
B.S. in Chemical Physics, University of Science and Technology of China, 2004