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Nancy J. Lin, Ph.D.

Research Interests

  • Bacterial biofilm-material interactions
  • Biofilm measurements
  • Dental polymers and composites
  • Antimicrobial materials
  • Mammalian cell response to materials  


Postdoctoral Research Opportunities through the National Research Council (NRC)

NIST-NRC Postdoctoral Fellowship: Two-year fellowship to work at NIST. Deadlines are Feb. 1 and Aug. 1. Application requires a 3000-word original research proposal. Stipend is over $65,000 per year plus benefits and relocation expenses. Open to U.S. citizens only. Please contact me if interested in writing a proposal on dental materials or biomaterials research, including:


Awards and Honors

  • U.S. Department of Commerce Bronze Medal Award "For advancing combinatorial methods..." (2010)
  • National Research Council (NRC/NIST) Postdoctoral Associateship, (2004-2006)
  • Graduate Fellowship from The Whitaker Foundation (1997-2003)
  • Graduate Fellowship Offer from the National Science Foundation (declined, 1997)



Peer-reviewed Publications

  • Chiang MY, Yangben Y, Lin NJ, Zhong JL, Yang L. (2013) Relationships among cell morphology, intrinsic cell stiffness and cell-substrate interactions. Biomaterials, 34(38): 9754-9762.     
  • Zhang K, Cheng L, Imazato S, Antonucci JM, Lin NJ, Lin-Gibson S, Bai Y, Xu HHK. (2013) Effects of dual antibacterial agents MDPB and nano-silver in primer on microcosm biofilm, cytotoxicity and dentin bond properties. Journal of Dentistry, 41(5): 464-474.     
  • Williams EH,Schreifels JA, Rao MV, Davydov AV, Oleshko VP, Lin NJ, Steffens KL, Krylyuk S, Bertness KA, Manocchi AK, Koshka Y. (2012) Selective streptavidin bioconjugation on silicon and silicon carbide nanowires for biosensor applications. Journal of Materials Research, 28: 68-77.    
  • Kraigsley AM, Tang K, Lippa KA, Howarter JA, Lin-Gibson S, Lin NJ. (2012) Effect of polymer degree of conversion on Streptococcus mutans biofilms. Macromolecular Bioscience, 12(12): 1706-1713.
  • Cheng L, Weir MD, Xu HHK, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. (2012) Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine. Dental Materials, 28: 573-583.
  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. (2012) Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. Dental Materials, 28: 561-572.
  • Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S, Fowler BO, Lin NJ. (2012) Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications. Dental Materials, 28(2): 219-228.
  • Fagan JA, Lin NJ, Zeisler R, Hight Walker AR. (2011) Effects of gamma irradiation for sterilization on aqueous dispersions of length sorted carbon nanotubes. Nano Research, 4(4): 393-404.
  • Moore NM, Lin NJ, Gallant ND, Becker ML. (2011) Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. Acta Biomaterialia, 7(5): 2091-2100.
  • Cheng YJ, Zeiger DN, Howarter JA, Zhang X, Lin NJ, Antonucci JM, Lin-Gibson S. (2011) In situ formation of silver nanoparticles in photocrosslinking polymers. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 97(1): 124-131.
  • Sun J, Ding Y, Lin NJ, Zhou J, Ro H, Soles CL, Cicerone MT, Lin-Gibson S. (2010) Exploring cellular contact guidance using gradient nanogratings. Biomacromolecules, 11(11): 3067–3072.
  • Ding Y, Sun J, Ro HW, Wang Z, Zhou J, Lin NJ, Cicerone MT, Soles CL, Lin-Gibson S. (2011) Thermodynamic underpinnings of cell alignment on controlled topographies. Advanced Materials, 23(3): 421-425.
  • Cheng YJ, Antonucci JM, Hudson SD, Lin NJ, Zhang X, Lin-Gibson S. (2011) Controlled in situ nanocavitation in polymeric materials. Advanced Materials, 23(3): 409-413.
  • Moore NM, Lin NJ, Gallant ND, Becker ML. (2010) The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials, 31(7):1604-1611.
  • Zeiger DN, Stafford CM, Cheng Y, Leigh SD, Lin-Gibson S, Lin NJ. (2010) Effects of sample preparation on bacterial colonization of polymers. Langmuir, 26(4): 2659-2664.
  • Lin NJ, Lin-Gibson S. (2009) Osteoblast response to dimethacrylate composites varying in composition, conversion and roughness using a combinatorial approach. Biomaterials, 30(27): 4480-4487.
  • Sun J, Fang R, Lin NJ, Eidelman N, Lin-Gibson S. (2009) Nondestructive quantification of leakage and its correlation with material performance parameters. Biomaterials, 30(27): 4457-4462.
  • Lin NJ, Hu HQ, Sung LP, Lin-Gibson S. (2009) Quantification of cell response to polymeric composites using a two-dimensional gradient platform. Combinatorial Chemistry & High Throughput Screening, 12(6): 619-625.
  • Lin-Gibson S, Sung LP, Forster AM, Hu H, Cheng Y, Lin NJ. (2009) Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays. Acta Biomaterialia, 5(6): 2084-2094.
  • Lin NJ, Drzal PL, Lin-Gibson S. (2007) Two-dimensional gradient platforms for rapid assessment of dental polymers: A chemical, mechanical and biological evaluation. Dental Materials, 23(10): 1211-1220.
  • Lin NJ, Bailey LO, Becker ML, Washburn NR, Henderson LA. (2007) Macrophage response to methacrylate conversion using a gradient approach. Acta Biomaterialia, 3(2): 163-173.
  • Meilander-Lin NJ, Cheung PJ, Wilson DL, Bellamkonda RV. (2005) Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin. Tissue Engineering, 11(3-4): 546-555.
  • Meilander NJ, Pasumarthy MK, Kowalczyk TH, Cooper MJ, Bellamkonda RV. (2003) Sustained release of plasmid DNA from lipid microtubules and agarose hydrogel. Journal of Controlled Release, 88: 321-331.
  • Meilander NJ, Yu X, Ziats NP, Bellamkonda RV. (2001) Lipid-based microtubular drug delivery systems. Journal of Controlled Release, 71: 141-152.  


Book Chapters and Contributions

  • Lin NJ, Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S. (2012) Positively-charged dimethacrylates to reduce bacterial attachment. Biomaterials Forum, 34(1):17-18.
  • Waters MS, Yang B, Lin NJ, Lin-Gibson S. (2011) Mechanics behind 4D interferometric measurement of biofilm mediated tooth decay. In Tom Proulx (Ed.), Optical Measurements, Modeling, and Metrology, Vol. 5 (pp. 337-344), New York: Springer.
  • Lin NJ, Sun J, Ding Y, Lin-Gibson S. (2010) Changes in cell orientation due to variations in nanograting height. Biomaterials Forum, 32(4): 31-32.
  • Meilander NJ, Lee HJ, Bellamkonda RV. (2009) Biomaterials to promote tissue regeneration. In M. Kutz (Ed.), Standard Handbook of Biomedical Engineering and Design, Second Edition, Vol. 1 (pp. 445-477), New York: McGraw-Hill.
  • Lin-Gibson S, Lin NJ, Landis FA. (2006) High-throughput evaluation of restorative dental polymers. Biomaterials Forum, 28(1): 21-23.
  • Meilander NJ, Bellamkonda RV. (2004) Lipid microtubules as sustained delivery vehicles for proteins and nucleic acids. In S. Svenson (Ed.), Carrier-based Drug Delivery, ACS Symposium Series 879 (pp. 85-97), Washington DC: American Chemical Society.
  • Meilander NJ, Bellamkonda RV. (2002) Biomaterials to promote tissue regeneration. In M. Kutz (Ed.), Standard Handbook of Biomedical Engineering and Design (pp. 16.1-16.29), New York: McGraw-Hill.
Photo of Nancy Lin


Biomedical Engineer
Biosystems and Biomaterials Division
Biomaterials Group

Employment History:

2012-present: Biomedical Engineer, NIST Biosystems and Biomaterials Division, Gaithersburg, MD

2006-2012: Biomedical Engineer, NIST Polymers Division, Gaithersburg, MD

2004-2006: NRC Postdoctoral Associate, NIST Polymers Division, Gaithersburg, MD

2002-2004: Graduate Research Assistant, Case Western Reserve University, Cleveland, OH

1997-2002: Whitaker Foundation Graduate Fellow, Case Western Reserve University, Cleveland, OH


Ph.D., Biomedical Engineering, Case Western Reserve University (2004)

B.S., summa cum laude, Mechanical Engineering, Valparaiso University (1997)


Phone: (301) 975-4935
Email: nancy.lin@nist.gov
Fax: (301) 975-4977