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NIST Authors in Bold
|Author(s):||Elijah J. Petersen; Pawel Jaruga; M Miral Dizdar; Bryant C. Nelson;|
|Title:||Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry|
|Published:||June 16, 2014|
|Abstract:||Mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of oxygen-derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using high resolution mass spectrometry for the quantification of oxidatively-induced DNA damage. We present results from recently published studies on the genotoxicity of National Institute of Standards and Technology (NIST) reference material (RM) gold nanoparticles (AuNPs) and on DNA damage in C. elegans after exposure to 10 nm silver nanoparticles (AgNPs).|
|Dates:||June 16-18, 2014|
|Keywords:||nanotoxicology, Comet assay, genotoxicity, biomarker, toxicology|
|Research Areas:||Nanotech/Environment, Health & Safety|
|PDF version:||Click here to retrieve PDF version of paper (726KB)|