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Publication Citation: Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry

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Author(s): Elijah J. Petersen; Pawel Jaruga; M Miral Dizdar; Bryant C. Nelson;
Title: Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry
Published: June 16, 2014
Abstract: Mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of oxygen-derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using high resolution mass spectrometry for the quantification of oxidatively-induced DNA damage. We present results from recently published studies on the genotoxicity of National Institute of Standards and Technology (NIST) reference material (RM) gold nanoparticles (AuNPs) and on DNA damage in C. elegans after exposure to 10 nm silver nanoparticles (AgNPs).
Proceedings: Nanotech 2014
Location: Washington, DC
Dates: June 16-18, 2014
Keywords: nanotoxicology, Comet assay, genotoxicity, biomarker, toxicology
Research Areas: Nanotech/Environment, Health & Safety
PDF version: PDF Document Click here to retrieve PDF version of paper (726KB)