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Publication Citation: Dose calibrator manufacturer-dependent bias in assays of 123I

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Author(s): Denis E. Bergeron; Jeffrey T. Cessna; Daniel B. Golas; Rheannan K. Young; Brian E. Zimmerman;
Title: Dose calibrator manufacturer-dependent bias in assays of 123I
Published: March 26, 2014
Abstract: Calibration factors for commercial ionization chambers (i.e. dose calibrators) were determined for a solution of 123I; the activity was based on the 1976 NBS standard. A link between the NIST standard and the International Reference System (SIR) was established. The two major U.S. dose calibrator manufacturers recommend oppositely biased calibration factors, giving a spread of 11.3 % in measured activities. With modern quantitative imaging techniques capable of ≤ 10 % accuracy, this bias for a SPECT nuclide is highly significant.
Citation: Applied Radiation and Isotopes
Pages: pp. 79 - 86
Keywords: Ionization chamber; dose calibrator; I-123; secondary standard; quantitative imaging
Research Areas: Medical Physics
DOI: http://dx.doi.org/10.1016/j.apradiso.2014.03.018  (Note: May link to a non-U.S. Government webpage)