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Publication Citation: Calibration of traceable solid mock I-131 phantoms used in an international SPECT image quantification comparison

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Author(s): Brian E. Zimmerman; Leticia S. Pibida; Lynne E. King; Denis E. Bergeron; Jeffrey T. Cessna; Matthew M. Mille;
Title: Calibration of traceable solid mock I-131 phantoms used in an international SPECT image quantification comparison
Published: August 15, 2013
Abstract: The International Atomic Energy Agency (IAEA) has organized an international comparison to assess Single Photon Emission Computed Tomography (SPECT) image quantification capabilities in 12 countries. Iodine-131 was chosen as the radionuclide for the comparison because of its wide use around the world, but for logistical reasons solid 133Ba sources were used as a long-lived surrogate for 131I. For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared. We also developed a technique using two different detection methods for individually calibrating the sources for 133Ba activity based on a National standard. This methodology allows for the activity calibration of each 133Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders. This level of uncertainty allows for these sources to be used for the intended comparison exercise, as well as in other SPECT image quantification studies.
Citation: Journal of Research (NIST JRES) - 118.017
Keywords: barium-133; iodine-131; SPECT; standards; traceability
Research Areas: Calibrations (Ionizing Radiation)
DOI: http://dx.doi.org/10.6028/jres.118.017