NIST logo

Publication Citation: Optimizing Instrument Operation and Data Processing for Single Particle Inductively Coupled Plasma Mass Spectrometry Measurement of Gold Nanoparticles

NIST Authors in Bold

Author(s): Jingyu Liu; Karen E. Murphy; Robert I. MacCuspie; Michael R. Winchester;
Title: Optimizing Instrument Operation and Data Processing for Single Particle Inductively Coupled Plasma Mass Spectrometry Measurement of Gold Nanoparticles
Published: May 16, 2013
Abstract: Inductively coupled plasma mass spectrometry (ICP-MS) operated in single particle mode is an attractive analytical tool capable of both sizing and counting metal containing nanoparticles in aqueous suspensions. In this study, we have evaluated the performance of single particle-ICP-MS (spICP-MS) for gold nanoparticle (AuNPs) characterization. Instrument operating parameters, test solution concentration and data processing were optimized for accurate size and particle number concentration measurement. We demonstrate that short measurement dwell time induces severe particle splitting between adjacent dwells, and the optimal dwell time, limiting both splitting and coincident particle events, is 10 ms. A pre-established protocol for particle size calculation using the measured aerosol transport efficiency and soluble standard calibration was examined over a range of AuNPs diameters from 10 nm to 200 nm. Finally, size measurements were performed on heterogeneous Au solutions containing both soluble Au and AuNPs.
Conference: Nanotech Conference 2013
Proceedings: Nanotech Conference Technical Proceedings
Volume: 1
Pages: pp. 151 - 154
Location: Washington, DC
Dates: May 12-16, 2013
Keywords: Single particle ICP-MS; nanomaterial characterization; gold nanoparticles
Research Areas: Characterization, Nanometrology, and Nanoscale Measurements
PDF version: PDF Document Click here to retrieve PDF version of paper (898KB)