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|Author(s):||David J. Vanderah; Marlon L. Walker; David T. Gallagher; Ryan Vierling; Fay Crawshaw;|
|Title:||Membrane protein resistance of oligo(ethylene oxide) self-assembled monolayers|
|Published:||July 31, 2014|
|Abstract:||Spectroscopic ellipsometry was used to evaluate the resistance to protein adsorption (RPA) of self- assembled monolayers (SAMs) of HS(CH2)3O(CH2CH2O)6M and [HS(CH2)3CH]2O-(CH2CH2O)6M, where M = CH3 or H, on Au. The SAMs were exposed to fibrinogen, a soluble protein frequently used to evaluate surface protein resistance properties, and rhodopsin, an integral membrane protein (IMP). Our results show that the nature of the oligo(ethylene oxide) end group is critical for surfaces to resist adsorption of IMPs as the methoxy-terminated SAMs (M = CH3) were found to adsorb rhodopsin, whereas when M = H the SAMs exhibited high RPA.|
|Citation:||Colloids and Surfaces B-Biointerfaces|
|Keywords:||"self-assembled monolayers, membrane proteins, protein resistance"|
|Research Areas:||Drugs/Pharmaceuticals, Bioscience & Health, Chemistry|
|DOI:||http://dx.doi.org/10.1016/j.colsurfb.2014.07.031 (Note: May link to a non-U.S. Government webpage)|