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Publication Citation: ,Real-worldŠ precision, bias, and between-laboratory variation for surface area measurement of a titanium dioxide nanomaterial in powder form

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Author(s): Vincent A. Hackley; Aleksandr B. Stefaniak;
Title: ,Real-worldŠ precision, bias, and between-laboratory variation for surface area measurement of a titanium dioxide nanomaterial in powder form
Published: June 01, 2013
Abstract: Accurate characterization of nanomaterial properties is a critical component of any nanotoxicology testing strategy. Data that describes the performance of various laboratories to measure the characteristics of the same nanomaterial is scarce. We conducted an inter-laboratory study to evaluate ,real-worldŠ precision and bias of specific surface area measurements. Each participant was provided a sample of NIST Standard Reference Material (SRM) 1898 (Titanium Dioxide Nanopowder) and a sample preparation and analysis protocol. Based on results from n = 19 laboratories, estimates of precision ranged from 0.10 % to 3.96 % and measurement bias was generally within ± 5 % of the certified surface area value of the material. Between-laboratory variability accounted for 91 % of the total variance and is likely explained by gravimetric errors. Reliable determination of intrinsic nanomaterial properties such as surface area will permit development of protocols for toxicity testing, verification of laboratory proficiency, and consistency in interpretation of toxicity study data.
Citation: Journal of Nanoparticle Research
Volume: 15
Pages: pp. 1742 - 1749
Keywords: Surface Area; Reference Material; Precision; Titanium Dioxide; Nanoparticle; Nanomaterial; Nanotoxicology; Gas Sorption; BET
Research Areas: Nanotech/Environment, Health & Safety, Nanostructured Materials, Nanomaterials, Characterization, Nanometrology, and Nanoscale Measurements
DOI: http://dx.doi.org/10.1007/s11051-013-1742-y  (Note: May link to a non-U.S. Government webpage)
PDF version: PDF Document Click here to retrieve PDF version of paper (233KB)