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Publication Citation: Biology and Genetics of New Autosomal STR Loci Useful for Forensic DNA Analysis

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Author(s): John M. Butler; Carolyn R. Steffen;
Title: Biology and Genetics of New Autosomal STR Loci Useful for Forensic DNA Analysis
Published: August 19, 2013
Abstract: Short tandem repeats (STRs) are regions of tandemly repeated DNA segments found throughout the human genome that vary in length (through insertion, deletion, or mutation) with a core repeated DNA sequence. Forensic laboratories commonly use tetranucleotide repeats, containing a four base pair repeat structure such as GATA. In 1997, the FBI Laboratory selected 13 STR loci that form the backbone of the U.S. national DNA database. Building on the European expansion in 2009, the FBI announced plans in April 2011 to expand the U.S. core loci to as many as 20 STRs to enable more global DNA data sharing. Commercial STR kits enable consistency in marker use and allele nomenclature between laboratories and help improve quality control. The STRBase website, maintained by the U.S. National Institute of Standards and Technology, contains helpful information on STR markers used in human identity testing.
Citation: Topics in Forensic DNA Analysis: Current Practices and Emerging Technologies
Publisher: CRC Press (Taylor & Francis), New York City, NY
Pages: pp. 181 - 198
Keywords: forensic science, DNA, forensic DNA, short tandem repeat, STR, STRBase
Research Areas: Human Identification/Molecular Biometrics
DOI: http://dx.doi.org/10.1201/b15361-13  (Note: May link to a non-U.S. Government webpage)