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|Author(s):||Robert F. Cook; Sang-Min Lee; De-Hao D. Tsai; Vincent A. Hackley; Martin W. Brechbiel;|
|Title:||Surface-Engineered Nanomaterials as X-ray Absorbing Adjuvant Agents for Auger-Mediated Chemo-Radiation|
|Published:||April 30, 2013|
|Abstract:||We demonstrate a prototype approach to formulate gold nanoparticle (AuNP)‹based X‹ray absorbing adjuvant agents through surface‹engineering of cisplatin pharmacophore (PtII) with lipoic acid‹modified polyacrylate (denoted as PtII‹AuNPs). Design of PtII‹AuNPs was examined and further validated using a combination of physicochemical characterization methods. Our results show PtII‹AuNPs exhibits very high capacity for PtII loading via the mechanism of multidentate coordination between PtII ions and surface‹bound polyacrylate. The PtII‹AuNP vector presented excellent colloidal stability in an acid‹sensitive manner that enables PtII drug‹release, and exhibited high in vitro cytotoxicity to the cancer cell lines MCF‹7 and SK‹OV‹3. Secondary electron emissions from both PtII and AuNPs are triggered by an external ionizing radiation source via the Auger cascade. As a result, PtII‹AuNPs exhibit therapeutic potential as an adjuvant agent for concurrent chemo‹radiation cancer therapy.|
|Pages:||pp. 5252 - 5256|
|Keywords:||gold nanoparticle, cisplatin, cancer therapy, chemo-radiation|
|Research Areas:||Nanobiotechnology, Nanochemistry, Characterization, Nanometrology, and Nanoscale Measurements, Bioscience & Health|
|DOI:||http://dx.doi.org/10.1039/c3nr00333g (Note: May link to a non-U.S. Government webpage)|
|PDF version:||Click here to retrieve PDF version of paper (890KB)|