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Publication Citation: Mass and momentum transport in microcavities for diffusion-dominant cell culture applications

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Author(s): Alvin G. Yew; Francisco J. Atencia; Alvin G. Yew; Adam Hsieh; Daniel Pinero;
Title: Mass and momentum transport in microcavities for diffusion-dominant cell culture applications
Published: March 01, 2013
Abstract: For the informed design of microfluidic devices, it is important to understand transport phenomena at the microscale. This letter outlines an analytically-driven approach to the design of rectangular microcavities extending perpendicular to a perfusion microchannel for microfluidic cell culture devices. We present equations to estimate the spatial transition from advection- to diffusion-dominant transport inside cavities as a function of the geometry and flow conditions. We also estimate the time required for molecules, such as nutrients or drugs to travel from the microchannel to a given depth into the cavity. These analytical predictions can facilitate the rational design of microfluidic devices to optimize and maintain long-term, physiologically-based culture conditions with low fluid shear stress.
Citation: Applied Physics Letters
Volume: 102
Issue: 8
Keywords: microfluidics;diffusion;cell culture;cavity flow
Research Areas: Nanofluidics