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NIST Authors in Bold
|Author(s):||Alvin G. Yew; Francisco J. Atencia; Alvin G. Yew; Adam Hsieh; Daniel Pinero;|
|Title:||Mass and momentum transport in microcavities for diffusion-dominant cell culture applications|
|Published:||March 01, 2013|
|Abstract:||For the informed design of microfluidic devices, it is important to understand transport phenomena at the microscale. This letter outlines an analytically-driven approach to the design of rectangular microcavities extending perpendicular to a perfusion microchannel for microfluidic cell culture devices. We present equations to estimate the spatial transition from advection- to diffusion-dominant transport inside cavities as a function of the geometry and flow conditions. We also estimate the time required for molecules, such as nutrients or drugs to travel from the microchannel to a given depth into the cavity. These analytical predictions can facilitate the rational design of microfluidic devices to optimize and maintain long-term, physiologically-based culture conditions with low fluid shear stress.|
|Citation:||Applied Physics Letters|
|Keywords:||microfluidics,diffusion,cell culture,cavity flow|