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Publication Citation: Certification of Total Arsenic in Blood and Urine Standard Reference Materials by Radiochemical Neutron Activation Analysis and Inductively Coupled Plasma - Mass Spectrometry

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Author(s): Rick L. Paul; William C. Davis; Karen E. Murphy; Colleen E. Bryan; Lee L. Yu; William F. Guthrie; Dennis D. Leber; Thomas W. Vetter;
Title: Certification of Total Arsenic in Blood and Urine Standard Reference Materials by Radiochemical Neutron Activation Analysis and Inductively Coupled Plasma - Mass Spectrometry
Published: March 01, 2014
Abstract: A newly developed procedure for determination of arsenic by radiochemical neutron activation analysis was used to measure arsenic in SRM 955c Toxic Elements in Caprine Blood and SRM 2668 Toxic Elements in Frozen Human Urine for the purpose of providing mass concentration values for certification. Samples were freeze-dried prior to analysis followed by neutron irradiation for 3 h at 1x1014cm-2s-1. After sample dissolution in perchloric and nitric acids, arsenic was separated from the matrix by extraction into zinc diethyldithiocarbamate in chloroform, and 76As quantified by gamma-ray spectroscopy. RNAA results were combined with ICP-MS values from NIST and collaborating laboratories to provide certified values.
Citation: Journal of Radioanalytical and Nuclear Chemistry
Volume: 299
Issue: 3
Pages: pp. 1555 - 1563
Keywords: neutron activation analysis; radiochemistry; inductively coupled plasma mass spectrometry; standard reference materials
Research Areas: Biological Product Characterization, Trace, Assessment, RNAA, Standards, Standard Reference Materials, Standard Reference Materials, Bioscience & Health, Chemistry, Mass Spectrometry, Measurements