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|Author(s):||Arlin B. Stoltzfus;|
|Title:||Mutation-Biased Adaptation in a Protein NK Model|
|Published:||October 01, 2006|
|Abstract:||Evolutionary trends responsible for systematic differences in genome and proteome composition have been attributed to GC:AT mutation bias in the context of neutral evolution or to selection acting on genome composition. A possibility that has been ignored, presumably because it is part of neither the Modern Synthesis nor the Neutral Theory, is that mutation may impose a directional bias on adaptation. This possibility is explored here with simulations of the effect of a GC:AT bias on amino acid composition during adaptive walks on an abstract protein fitness landscape called an ,NKŠ model. The results indicate that adaptation does not preclude mutation-biased evolution. In the complete absence of neutral evolution, a modest GC:AT bias of realistic magnitude can displace the trajectory of adaptation in a mutationally favored direction, to such a degree that amino acid composition is biased substantially and persistently. Thus, mutational explanations for evolved patterns need not presuppose neutral evolution.|
|Citation:||Molecular Biology and Evolution|
|Pages:||pp. 1852 - 1862|
|Keywords:||mutation bias, GC content, NK model, simulation, adaptive evolution, adaptive walk|