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Publication Citation: Recent Advances in Electrochemical Glyco-biosensing

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Author(s): Rebecca A. Zangmeister; Germarie Sanchez-Pomales;
Title: Recent Advances in Electrochemical Glyco-biosensing
Published: April 08, 2011
Abstract: Biosensors based on electrochemical transduction mechanisms have recently made advances into the field of glycan analysis. These glyco-biosensor assays offer simple, rapid, sensitive and economical approaches to the measurement need for rapid glycan analysis for biomarker detection, cancer and disease diagnostics, and bioprocess monitoring of therapeutic glycoproteins. Although the prevalent methods of glycan analysis (high performance liquid chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy) provide detailed identification and structural analysis of glycan species, there are significantly few rapid glycan assays available for diagnostic and screening applications. Here we review instances in which glyco-biosensors have been used for glycan analysis using a variety of electrochemical transduction mechanisms (e.g. amperometric, potentiometric, impedimetric and voltammetric), selective binding agents (e.g. lectins and antibodies) and redox species (e.g. enzyme substrates, inorganic, and nanomaterial).
Citation: International Journal of Electrochemistry
Volume: 2011
Pages: 11 pp.
Keywords: bacteria; biomarkers; biosensor; cyclic voltammetry; differential pulse voltammetry; electrochemical; electrochemical impedance spectroscopy; glycan; glycosylation; lectin; potentiometry; protein; pulsed amperometric detection; square wave voltammetry
Research Areas: Biological Product Characterization, Molecular Pathology, Electroanalytical, Drugs/Pharmaceuticals, Industrial Biochemical Manufacturing, Clinical Diagnostics, Cell-Based, Biomanufacturing, Diagnostics, Bioscience & Health
DOI: http://dx.doi.org/10.4061/2011/825790  (Note: May link to a non-U.S. Government webpage)
PDF version: PDF Document Click here to retrieve PDF version of paper (1MB)