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|Author(s):||Joseph M. Antonucci; Drago Skrtic;|
|Title:||Fine-tuning of polymeric resins and their interfaces with amorphous calcium phosphate. A strategy for designing effective remineralizing dental composites|
|Published:||September 29, 2010|
|Abstract:||For over a decade our group has been designing, preparing and evaluating bioactive, remineralizing composites based on amorphous calcium phosphate (ACP) fillers embedded in polymerized methacrylate resin matrices. In these studies a major focus has been on exploring structure-property relationships of the matrix phase of these composites on their anti-cariogenic potential. Main challenges were to gain a better understanding of polymer matrix/filler interfacial properties through controlling the surface properties of the fillers or via fine-tuning of the resin matrix. In this work, we describe the effect of chemical structure and composition of the resin matrices on some of the critical physicochemical properties of the copolymers and their ACP composites. Such structure-property studies are essential in formulating clinically effective products, and this knowledge base is likely to have strong impact on the future design of therapeutic materials, appropriate for mineral restoration in defective tooth structures.|
|Pages:||pp. 378 - 392|
|Keywords:||adhesion, amorphous calcium phosphate, degree of vinyl conversion, mechanical strength, methacrylate monomers, polymerization, structure-property relationship, water sorption.|
|Research Areas:||Materials Science, Biomaterials, Polymers|
|PDF version:||Click here to retrieve PDF version of paper (229KB)|