Take a sneak peek at the new NIST.gov and let us know what you think!
(Please note: some content may not be complete on the beta site.).
NIST Authors in Bold
|Author(s):||Martin Y. Chiang; Joy P. Dunkers;|
|Title:||AN ANALYTICAL SOLUTION FOR FLEXIBLE SUBSTRATES UNDERGOING SMALL EQUIBIAXIAL STRAINS|
|Published:||June 17, 2009|
|Abstract:||Cells can distinguish between different types of mechanical signals, such as stretch (tension), pressure (compression), and shear, to guide mechanosensitive cellular activities. Cell culture systems with controlled delivery of a mechanical input such as substrate strain, hydrostatic pressure, or fluid shear stress are used for the in vitro application of these forces. The work reported here uses a system that imparts equibiaxial loading on a flexible substrate to study cell response to stretch, similar to the Bioflex in the Flexcell family of products. The objective of this study is to introduce an analytical (closed-form) solution of the relationship between the substrate strain and pressure under small strains, less than 2%. The solution is derived from the superposition of two elastic responses induced in the equibiaxial strain culture system after applying pressure.|
|Proceedings:||ASME 2009 Summer Bioengineering Conference|
|Location:||Lake Tahoe, CA|
|Dates:||June 17-21, 2009|
|Keywords:||Cell Culture, Flexcell, Strain-Pressure|
|Research Areas:||Bioscience & Health|