| Author(s): |
Brian E. O'Neill; Howard Vo; Mary Angstadt; Victor Frenkel; Bradford Wood; Timothy P. Quinn; |
| Title: |
Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery |
| Published: |
December 03, 2007 |
| Abstract: |
The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery. |
| Conference: |
2007 IEEE Int'l. Ultrasonic Symposium |
| Pages: |
pp. 1 - 4 |
| Location: |
New York, NY |
| Dates: |
October 28-31, 2007 |
| Keywords: |
drug delivery;high intensity focused ultrasound;hyperthermia;thermal mechanism |
| Research Areas: |
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| PDF version: |
 Click here to retrieve PDF version of paper (869KB) |
