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|Author(s):||Brian E. O'Neill; Howard Vo; Mary Angstadt; Victor Frenkel; Bradford Wood; Timothy P. Quinn;|
|Title:||Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery|
|Published:||December 03, 2007|
|Abstract:||The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.|
|Conference:||2007 IEEE Int'l. Ultrasonic Symposium|
|Pages:||pp. 1 - 4|
|Location:||New York, NY|
|Dates:||October 28-31, 2007|
|Keywords:||drug delivery,high intensity focused ultrasound,hyperthermia,thermal mechanism|
|PDF version:||Click here to retrieve PDF version of paper (890KB)|