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Publication Citation: Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery

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Author(s): Brian E. O'Neill; Howard Vo; Mary Angstadt; Victor Frenkel; Bradford Wood; Timothy P. Quinn;
Title: Investigations into the potential contribution of a thermal mechanism for pulsed-high intensity focused ultrasound mediated delivery
Published: December 03, 2007
Abstract: The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.
Conference: 2007 IEEE Int'l. Ultrasonic Symposium
Pages: pp. 1 - 4
Location: New York, NY
Dates: October 28-31, 2007
Keywords: drug delivery;high intensity focused ultrasound;hyperthermia;thermal mechanism
Research Areas:
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