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|Author(s):||David Serrell; Jera Law; Andrew J. Slifka; Roop L. Mahajan; Dudley S. Finch;|
|Title:||A Uniaxial bioMEMS device for imaging single cell response during quantitative force-displacement measurements|
|Published:||December 01, 2008|
|Abstract:||Mechanical forces play a key role in many cellular processes such as apoptosis and differentiation. A microfabricated device has been developed for imaging of a single, adherent cell while quantifying force under an applied strain. The device works in a similar fashion to a displacement-controlled uniaxial tensile machine. The device was calibrated using a tipless AFM cantilever and shows excellent agreement with the calculated spring constant. A step input was applied to a single, adherent fibroblast cell and the viscoelastic response was characterized with a mechanical model. The adherent fibroblast was imaged using fluorescence and phase contrast techniques.|
|Pages:||pp. 883 - 889|
|Keywords:||bioMEMS,cell mechanics, fibroblast|
|Research Areas:||Medical Devices|
|PDF version:||Click here to retrieve PDF version of paper (338KB)|