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Publication Citation: The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores

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Author(s): John J. Kasianowicz; Jeffrey C. Lerman; Sarah E. Henrickson; Martin Misakian; Rekha Panchal; Kelly Halverson; Sina Bavari; Tam Nguyen; Rick Gussio; Devanand K. Shenoy; Vincent M. Stanford;
Title: The Detection and Characterization of Ions, DNA and Proteins with Nanometer-Scale Pores
Published: December 01, 2007
Abstract: Protein ion channels are nanometer-scale pores that are central to many biological processes, including the sensing of a wide variety of molecules. They have also demonstrated their potential for use in the sensitive and selective detection of ions, the characterization of polynucleotides, and toxins as well as the screening of a therapeutic agent against a key lethal anthrax protein. Further advances in materials engineering, theory, and signal processing are needed to enable practical applications based on biological or synthetic nanopores.
Citation: Handbook of Biosensors and Biochips
Publisher: J. Wiley & Sons, Ltd., West Sussex, UK
Pages: pp. 811 - 830
Keywords: analyte detection;anthrax;ion channels;nanopores;stochastic sensing
Research Areas: Nanoelectronics and Nanoscale Electronics