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Life Sciences Programs & Projects

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Standards for Immuno-Histochemical Imaging: A Biomarker Protein Expression Chip
Last Updated Date: 01/14/2015

Immunohistochemistry (IHC) is used to visualize antigens in tissue sections by specific antigen-antibody interactions, an advantage over … more

Protection Against Ionizing Radiation in Extreme Radiation-Resistant Microorganisms
Last Updated Date: 01/14/2015

We measured the levels of modified DNA bases following ?-irradiation of the halophilic archaeon, Halobacterium sp. str. NRC-1. In this first study … more

Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA
Last Updated Date: 01/14/2015

We utilized isotope-dilution liquid chromatography/mass spectrometry (LC/MS) to determine the levels of the oxidatively damaged DNA bases, … more

Controlling Microfluidic Cell Culture Environments
Last Updated Date: 01/14/2015

NIST has taken advantage of recent technological advances to develop polymer microfluidic cell culture systems that provide a level of control … more

Bioimaging
Last Updated Date: 12/01/2014

Our goal is to develop methods and materials for imaging-based characterization of molecular signatures that occur during cellular proliferation, … more

Fluorescence Microscope Benchmarking
Last Updated Date: 08/25/2014

We have made available a method to characterize a fluorescence microscope's performance by benchmarking the detection threshold, saturation and … more

Collagen Films Protocol
Last Updated Date: 05/08/2013

Background: Collagen type 1 is the most prevalent extracellular protein in connective tissue, and is part of the family of collagens that are … more

Digital PCR
Last Updated Date: 04/26/2013

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR … more

SRM for Huntington CAG Repeat
Last Updated Date: 03/15/2013

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by … more

Genome in a Bottle Consortium
Last Updated Date: 03/15/2013

NIST has organized the "Genome in a Bottle Consortium" to develop the reference materials, reference data, and reference methods needed to assess … more

Development of a Collagen Fibril Reference Material for Reproducible Cell Response
Last Updated Date: 01/11/2013

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which … more

Surface Plasmon Resonance Imaging of Cells and Extracellular Matrix Proteins
Last Updated Date: 10/10/2012

A critical challenge in cell biology is imaging and quantifying the interactions of cells with their extracellular matrix (ECM) environment, and … more

Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells
Last Updated Date: 10/10/2012

To accurately interpret the data from fluorescent proteins as reporters of gene activation within living cells, it is important to understand the … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging
Last Updated Date: 10/10/2012

A collaboration between the Medical University of South Carolina (MUSC), Hollings Marine Laboratory, and NIST is examining the relationship … more

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