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Life Sciences Programs & Projects

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Digital PCR
Last Updated Date: 04/26/2013

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR … more

SRM for Huntington CAG Repeat
Last Updated Date: 03/15/2013

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by … more

Genome in a Bottle Consortium
Last Updated Date: 03/15/2013

NIST has organized the "Genome in a Bottle Consortium" to develop the reference materials, reference data, and reference methods needed to assess … more

Development of a Collagen Fibril Reference Material for Reproducible Cell Response
Last Updated Date: 01/11/2013

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which … more

Photodetector Analysis for Biological Agent Detection
Last Updated Date: 11/16/2012

Photomultiplier tube (PMT) analysis with respect to PMT sensitivity and long-term stability using synchrotron radiation.

Surface Plasmon Resonance Imaging of Cells and Extracellular Matrix Proteins
Last Updated Date: 10/10/2012

A critical challenge in cell biology is imaging and quantifying the interactions of cells with their extracellular matrix (ECM) environment, and … more

Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells
Last Updated Date: 10/10/2012

To accurately interpret the data from fluorescent proteins as reporters of gene activation within living cells, it is important to understand the … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging
Last Updated Date: 10/10/2012

A collaboration between the Medical University of South Carolina (MUSC), Hollings Marine Laboratory, and NIST is examining the relationship … more

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Last Updated Date: 10/10/2012

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a … more

Cell-based Immunofluorescence Assays
Last Updated Date: 10/10/2012

Microscopy images of cells are often used in cell biology to qualitatively identify features of interest and to discern differences between … more

Multiparametric Measurement and Analysis of Cell Behavior on Extracellular Matrices
Last Updated Date: 10/10/2012

Cell responses to their culture environment always involve more than one component. An understanding of the relation between the physical and … more

Rapid Multiplex PCR
Last Updated Date: 10/08/2012

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR … more

Site-Specific Bioimaging
Last Updated Date: 10/02/2012

In collaboration with scientists at the Laboratory for Cell Biology (LCB) within the National Cancer Institute (NCI) of the National Institutes of … more

Ontologies and Interoperability in Evolutionary Comparative Analysis
Last Updated Date: 10/01/2012

Many computer-based inferences in contemporary biology are comparative and would benefit from the rigorous and flexible approach of evolutionary … more

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