Dr. Jeffrey W. Hudgens

Dr. Jeffrey W. Hudgens

Jeffrey.Hudgens -at- nist.gov

 

Chemical and Biochemical Reference Division

100 Bureau Drive, Mail Stop 8320
Gaithersburg, MD 20899-8320

Fax: 301-869-4020

 
Phone: (301) 975-2512

Office Location: B366, Physics Building (221)

 
Ligand exchange reaction
A important ligand exchange reaction observed by ESI-MS during  the synthesis of diphosphine-protected gold clusters. The computed reaction coordinate diagram is also shown.  See J. Phys. Chem. C 112, 12808–12814 (2008).

NIST/NRC Postdoctoral Opportunities (applications are due 1 FEB 2009; then 1 AUG 2009)

 List of Publications and Patents

Research Interests

  • Chemical and physical properties of ligand layered nanoparticles as determined with tandem mass spectrometry and optical spectroscopy
  • Reaction mechanisms leading to nanoparticle formation and modification
  • Reaction mechanisms of nanoparticles as they degrade in simulated in vivo and terrestrial environments
  • Covalent and noncovalent bonding interactions between nanoparticles and biological substrates
  • Physical-chemical characterization of metal atom-peptide,  metal-carbohydrate, and of enzyme-substrate complexes
  • Reaction mechanisms of enzymes determined under pre-equilibrium conditions
  • Properties of enzyme-substrate complexes
Au11(1,3-Bis(diphenylphosphino)propane)5 model
Gold nanoparticles [Au11(1,3-Bis(diphenylphosphino)propane)5] in methanol solution and its molecular model

Some Past Research Areas

Useful Resources

  1. Table of circulant Simplex Sequences 
  2. Labview Function library of 540 circulant simplex vectors and their inverses
  3. ACUCHEM kinetics simulation program (coming soon)

Education & Employment

BS Chemistry, 1971, Miami University
PhD Physical Chemistry, 1976, University of Illinois at Urbana
NRC Postdoc (Naval Research Laboratory), 1975-1977
Naval Research Laboratory Staff, 1977 – 1984
♦ Mass Spectrometry Section, 1977-1981
♦ Chemical Kinetics Section, 1981-1984
NBS/NIST staff, 1984-present
ESI-IMS-QTOF-MS instrument
ESI-IMS-qTOF-MS instrument. This tandem instrument volatilizes ions with its electrospray ionization source (ESI) and separates them in accord with their mobility in argon (IMS). The structure of each size-resolved ion is then probed with tandem MS/MS mass spectrometry (qTOF-MS).

Certain commercial materials and equipment are identified on this website in order to adequately specify the experimental protocol. Such identification neither implies recommendation or endorsement by the National Institute of Standards and Technology nor does it imply that the material or equipment identified is the best available for the purpose.

Updated 11/26/2008