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Information Science Standards to
Enable Biomedical Research

Satellite meeting for “Digital Biology: The Emerging Paradigm”

November 4-5, 2003             Bethesda, Maryland

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Tuesday, November 4th, 2003
Keynote Session

Session Chair:

8:30- 8:45 Dr. Arden Bement, NIST Director
Converging Technologies: Physical & Biological Sciences

8:45- 9:30 Dr. Robert Robbins, Fred Hutchinson Cancer Research Center
Institutional Standards – The Critical Missing Piece

9:30- 10:15 Professor John Wooley, UC San Diego
Computing 21st Century Biology

10:15 10:45 Break

10:45- 11:30 Dr. Jim Ostell, NCBI/NIH
NCBI/NIH Surfing the Information Tsunami at NCBI

11:30- 12:15 Dr. Jill Kaufman, IBM Life Sciences
Emerging Life Sciences Standards

12:15 pm - 1:30 pm Lunch

Focused Session 1: Biomedical Data Integration Standards

Session Chair: Dr. Milton Corn, National Library of Medicine, NIH

1:30-2:00 Dr. Monica Crubezy, Stanford Medical Informatics, Stanford University
Using Ontologies for Data and Semantic Integration

2:00-2:30 Dr. David Benton, Informatics and Knowledge Management, GlaxoSmithKlein
Issues in Information Integration for Drug Discovery

2:30-3:00 Dr. Gary Bader, Computational Biology Center, Memorial Sloan-Kettering Cancer Center
BioPAX - A Data Exchange Format for Biological Pathways

3:00-3:30 Break

3:30-4:00 Professor Bruno W.S. Sobral, Virginia Bioinformatics Institute, Virginia Tech
A Life Scientist's Road to Interoperability of Data and Tools

4:00-4:30 Professor Michael Vannier, Department of Radiology, University of Iowa
Integration of In Vivo Imaging Data: What's missing?

4:30-5:30 Panel Discussion, led by Chairman Corn. Some topics to get started: How can the vast variety of relevant biomedical information (from data to knowledge) be integrated where it is required? Can we develop some data integration standards that facilitate seamless integration of systems from different areas, and allow synthesis of knowledge from systems with different ontologies? What other types of standards can facilitate the integration of data/information/knowledge (e.g. physical standards for various types of imaging; standards for determining fidelity of machine learning in systems for diagnosis from fused data? Is it possible to build a roadmap for such standards, and what are the underlying scientific ideas that will be required for the roadmap to work (or maybe even just to be laid out)? What is happening already that is promising, and what things are missing that need to be done?

Panel: Session chair, All speakers, Dr. Larry Reeker; NIST, Dr. Steve Ray; NIST, with interaction of audience.

6:00 pm - 7: 00pm Cocktails; Cash Bar

7:00 pm Dinner, Dr. Juan Enriquez , Speaker
Joint dinner with other BISTIC satellite meeting "Systems Biology: Information Processing in the Biological Organism"


Wednesday, November 5th, 2003
Focused Session 2: Networked Science Standards

Session Chair: Kevin Mills, Senior Research Scientist in the Advanced Network Technologies Division, NIST

8:40-9:10 Dr. Kenneth H. Buetow, Director NCI Center for Bioinformatics, OD, NCI, NIH; Chief Laboratory of Population Genetics, CCR, NCI, NIH
The NCI Center for Bioinformatics (NCICB): building a foundation for in silico Cancer Research

9:10-9:40 Dr. Richard Hilderbrandt, Program Director for Advanced Computational Infrastructure
TeraGrid, a Powerful New Research Tool for Digital Biology

9:40-10:15 Dr. Ian Foster, Associate Director and Professor, Argonne National Laboratory and University of Chicago
Future Scientific Infrastructure

10:15-10:50 Dr. Andrew Grimshaw, Founder and Chief Technology Officer, Avaki
Creating Value with Data Grids and Life Sciences

10:50-11:00 Break

11:00-12:00 Panel Discussion led by Chairman Su. Some topics to get started: What information standards are needed to harness the computing power of grid networks? What current standards exist and what organizations are active in development of the standards? Where are "standards" not standards - i.e. what competing views of standards have been offered by different organizations? What standards are critical to the development of grid technologies to enable necessary scientific advancements over the next ten years? What standards may be needed specific to the Teragrid? What advances are awaiting standards - i.e. what would additional standards enable grid computing to become? Are specific standards necessary to enable grid computing in the life sciences environment?

Panel: Session chair and all speakers with audience participation.

12:00 - 1:30 Lunch

Focused Session 3: Quantitative Computational Biology

Session Chairs: Dr. Gary Gilliland and Dr. Ram D. Sriram, NIST

1:30 - 1:55 Dr. Arlin Stoltzfus, Research Biologist, NIST
NIST Models of Protein Evolution

1:55 - 2:20 Professor Atul Butte and Dr. Keith Elliston, GENSTRUT
Integration of Machine Learning, Genomics, and other tools in the Drug Discovery Process

2:20 - 2:45 Professor John Doyle, Caltech
ERATO Systems Biology Workbench

2:45 - 3:10 Dr. Sri Kumar, Program Manager, DARPA BIOCOMP Program
Standards for Cell Models: DARPA BioCOMP Experience

3:10 - 3:35 Break

3:35 - 4:00 Professor Robert S. Eisenberg, Bard Professor and Chairman, Dept. of Molecular Biophysics and Physiology, Rush Medical Center, Chicago
Calibrating Models of Channels and Proteins

4:00 - 5:00: Panel Discussion

  • What do you see as the trends in Quantitative Computational Biology (QCB)?
  • What is the current state of data standards--both at the domain level and at the interface level-- that impact your area of QCB)?
  • What do you perceive as the gaps in integrating tools and techniques in quantitative computational biology?
  • What are the opportunities for developing data standards that can fill these gaps?
  • What kinds of roles do you see for NIST and NIH for advancing the state of the art in QCB?

5:00 Wrap up and determine key points for the report

Date created: 7/24/03
Last Updated: 11/10/03
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