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Diagnostics Programs & Projects

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Digital PCR
Last Updated Date: 04/26/2013

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR … more

SRM for Huntington CAG Repeat
Last Updated Date: 03/15/2013

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by … more

Genome in a Bottle Consortium
Last Updated Date: 03/15/2013

NIST has organized the "Genome in a Bottle Consortium" to develop the reference materials, reference data, and reference methods needed to assess … more

Metallomics: A Multidisciplinary Approach for the Qualitative and Quantitative Determination of Proteins and Metalloproteins Used as Health and Disease Markers
Last Updated Date: 03/13/2013

As healthcare shifts from management of disease to management of health, there will be a necessary shift toward development of quantitative health … more

Instrumented Bioreactors
Last Updated Date: 12/17/2012

Our goal is to develop novel bioreactors that combine mechanical stimulation with integrated sensing to enable real-time optimization of the … more

Photodetector Analysis for Biological Agent Detection
Last Updated Date: 11/16/2012

Photomultiplier tube (PMT) analysis with respect to PMT sensitivity and long-term stability using synchrotron radiation.

Micronutrients Measurement Quality Assurance Program
Last Updated Date: 11/16/2012

The Micronutrients Measurement Quality Assurance Program , coordinated by the Chemical Sciences Division, supports measurement technology for … more

Fundamental Chemical Metrology
Last Updated Date: 10/22/2012

The Chemical Sciences Division serves as the Nation’s reference laboratory for chemical compositional measurements and standards to enhance U.S. … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Last Updated Date: 10/10/2012

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a … more

Chemical Characterization of Nanomaterial Formulations for Cancer Treatment in Support of the NCI Nanotechnology Characterization Laboratory
Last Updated Date: 10/02/2012

New generations of nanoparticles are being developed to provide early-stage detection and treatment of cancer. Much of the evaluative work on … more

Superresolving Optical Microscopy
Last Updated Date: 10/02/2012

Light microscopy is a widely used analytical tool because it provides non-destructive, real-time, three-dimensional imaging with chemical and … more

Site-Specific Bioimaging
Last Updated Date: 10/02/2012

In collaboration with scientists at the Laboratory for Cell Biology (LCB) within the National Cancer Institute (NCI) of the National Institutes of … more

Quantification of Cells with Specific Phenotypic Characteristics
Last Updated Date: 10/01/2012

Flow cytometers are versatile instruments that have been successfully used to enumerate cell subsets in infectious diseases (e.g., HIV) and to … more

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