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Welcome

The Bioassay Methods Group develops and applies standards and methods for all analytical and bioanalytical measurements pertinent to instrument calibration and validation to ensure bioassay performance for identification and quantitation of molecular and biological species; investigates fundamental biological processes by means of spectroscopy, electrochemistry, calorimetry, and molecular biology measurements to develop new and improved techniques, methodologies, and standards; uses state-of-the-art techniques and methods to explore and resolve measurement issues in molecular biology, nanobiotechnology, immunology, biophysical chemistry, molecular spectrometry and surface chemistry; works with users and manufacturers of analytical and bioanalytical instruments to assess method performance and to determine and address existing and future standards needs ranging from device calibration and instrument performance to the development of biological reference materials and procedures; works cooperatively with other government agencies and laboratories to improve the quality and reliability of their measurements in the biological sciences; and supports a broad range of health, defense, environmental, and energy research related activities and customers.

Programs/Projects
Biocompatibility of Photoluminescent Silicon Nanoparticles — Photoluminescent silicon nanoparticles have a bright and stable fluorescence and are promising candidates for use in bio-imaging, cell staining and drug delivery. In collaboration …
 
Decontamination of Biological Threats in Water Supplies — The availability of safe pure drinking water in the United States is taken for granted. The presence of dangerous microorganisms, viruses and toxins in our water systems can result in death, damage …
 
Fluorescence and Raman Intensity Correction Standards — Luminescence measurements have become the methods of choice for new clinical and biochemical analyses due to their high selectivity and sensitivity. At the same time, the use of Raman measurements …
 
Quantification of Cells with Specific Phenotypic Characteristics — Flow cytometers are versatile instruments that have been successfully used to enumerate cell subsets in infectious diseases (e.g., HIV) and to diagnose malignancies through changes in the …
 
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Contact

General Information:
Dr. Steven Choquette
Group Leader
301-975-3096 Telephone
301-977-0587 Facsimile

100 Bureau Drive, M/S 8312
Gaithersburg, MD 20899-8312