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Thomas Kole

Thomas Kole is a CNST Visiting Fellow in the Nanofabrication Research Group and a resident physician in the Department of Radiation Oncology at Georgetown University Hospital. He received a B.S. in Chemical Engineering and a Ph.D. in Chemical and Biomolecular Engineering from The Johns Hopkins University, and an M.D. from the University of Medicine and Dentistry of New Jersey (New Jersey Medical School). His doctoral research involved the development of novel rheological techniques used to characterize the mechanical properties of living cells and identify major signaling pathways involved in their regulation. As a Postdoctoral Fellow in the Sidney Kimmel Cancer Center at The Johns Hopkins University School of Medicine, he developed proteomic tools for the identification and analysis of key regulators in the adaptive immune response. Thomas is working with Samuel M. Stavis to develop measurement methods based on nanofluidic devices and fluorescence microscopy for cancer diagnostics.


Selected Publications: 

  • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, G. M. Delgoffe, T. P. Kole, Y. Zheng, P. E. Zarek, K. L. Matthews, B. Xiao, P. F. Worley, S. C. Kozma, and J. D. Powell, Immunity 30, 832–844 (2009).
  • A role for mammalian target of rapamycin in regulating T cell activation versus anergy, Y. Zheng, S. L. Collins, M. A. Lutz, A. N. Allen, T. P. Kole, P. E. Zarek, and J. D. Powell, Journal of Immunology 178, 2163–2170 (2007).
  • Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin, S. L. Gupton, K. L. Anderson, T. P. Kole, R. S. Fischer, A. Ponti, S. E. Hitchcock-DeGregori, G. Danuser, V. M. Fowler, D. Wirtz, D. Hanein, and C. M. Waterman-Storer, Journal of Cell Biology 168, 619–631 (2005).
  • Intracellular mechanics of migrating fibroblasts, T. P. Kole, Y. Tseng, I. Jiang, J. L. Katz, and D. Wirtz, Molecular Biology of the Cell 16, 328–338 (2005).
  • Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking, Y. Tseng, J. S. H. Lee, T. P. Kole, I. Jiang, and D. Wirtz, Journal of Cell Science 117, 2159–2167 (2004).
  • Micromechanical mapping of live cells by multiple-particle-tracking microrheology, Y. Tseng, T. P. Kole, and D. Wirtz, Biophysical Journal 83, 3162–3176 (2002).
Staff Photo Thomas Kole


CNST Visiting Fellow
Nanofabrication Research Group


B.S. Chemical Engineering – The Johns Hopkins University

Ph.D. Chemical and Biomolecular Engineering – The Johns Hopkins University

M.D. – University of Medicine and Dentistry of New Jersey (New Jersey Medical School)


Phone: 301-975-4675