Clinical diagnostics

News and Updates

Tiny red cylinder probes are presented in front of a much larger ice cube.

Spotlight: Shape-Shifting Probes Will Help Improve MRI Imaging

April 12, 2024

Not all gems are the precious stone kind. In the field of magnetic resonance imaging (MRI), a type of microscopic magnetic probes called geometrically encoded

NIST Researchers Use Cellphone Compass to Measure Tiny Concentrations of Compounds Important for Human Health

April 1, 2024

Nearly every modern cellphone has a built-in compass, or magnetometer, that detects the direction of Earth’s magnetic field, providing critical information for

NIST’s Ultra-small, Shape-shifting GEMS Offer an Easier and Cheaper way to improve MRI Imaging

December 20, 2023

Microscopic magnetic probes that change shape in response to their environment may greatly enhance magnetic resonance imaging (MRI). However, producing the

Projects and Programs

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

A new collaboration between NIST's Human Genomics Team, Mass Spectrometry Data Center, and Information Technology Laboratory to use and develop artificial

Genome in a Bottle

Ongoing

Consortium hosted by NIST dedicated to authoritative characterization of benchmark human genomes. Sign up for General GIAB and Analysis Team email lists

Computer-generated image of the structure for C-reactive protein

Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum

Completed

C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels

Digital PCR

Ongoing

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for

Publications

Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass

April 2, 2024

Author(s)

Mark Ferris, Gary Zabow

Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone

Certification of Standard Reference Material® 1595a Tripalmitin

March 1, 2024

Author(s)

Michael Nelson, Jerome Mulloor, Brian Lang, Blaza Toman, Antonio Possolo, William Perry, Alicia Lyle

Standard Reference Material (SRM) 1595a Tripalmitin is a high purity chemical substance having a certified value for purity, expressed as a mass fraction. It is

Digital PCR for the Characterization of Reference Materials

February 14, 2024

Author(s)

Megan Cleveland, Hua-Jun He, Mojca Milavec, Young-Kyung Bae, Peter Vallone, Jim Huggett

Well characterized reference materials are essential to ensuring the harmonization and accuracy of nucleic acid-based tests (such as qPCR); digital PCR (dPCR)

Evolution and Impact of Standard Reference Materials (SRMs) for the Determining Vitamin D Metabolites

January 18, 2024

Author(s)

Stephen Wise, Adam Kuszak, Johanna Camara

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health, Office of Dietary Supplements (NIH ODS)

Software

NIST's Integrated Colony Enumerator (NICE)

January 4, 2021

Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size

Curated Archive for COVID-19 Research Challenge Dataset (cord19-cdcs-nist)

This GitHub repository contains a downloadable snapshot of National Institute of Standards and Technology's COVID-19 Data Repository, curated from the COVID-19