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Chemistry Programs & Projects

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Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Last Updated Date: 10/10/2012

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a … more

26plex Autosomal Short Tandem Repeat Assay
Last Updated Date: 10/08/2012

A short tandem repeat (STR) multiplex assay was developed with 25 autosomal loci plus the sex-typing locus amelogenin for a total of 26 amplified … more

Rapid Multiplex PCR
Last Updated Date: 10/08/2012

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR … more

Chemical/Biochemical Microsensor Science
Last Updated Date: 10/02/2012

The Process Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and … more

Assessing the Internal Structure and Composition of Climatically-Relevant Atmospheric Particles
Last Updated Date: 10/02/2012

Atmospheric particles with long atmospheric lifetimes affect Earth's radiative balance. These particles typically consist of multiple chemical … more

Energy Determination of X-Ray Transition Energies Using the NIST TES Microcalorimeter Detector
Last Updated Date: 10/02/2012

Previous efforts to produce a comprehensive tabulation of atomic x-ray transition energies have been hampered by the fact that a) detectors having … more

Site-Specific Bioimaging
Last Updated Date: 10/02/2012

In collaboration with scientists at the Laboratory for Cell Biology (LCB) within the National Cancer Institute (NCI) of the National Institutes of … more

Polymer Microspheres By Annular Co-Flow Extrusion
Last Updated Date: 10/02/2012

Well characterized test materials are essential for validating the performance of trace explosive detection systems. Particle size, chemical … more

Next-Generation Metrology for Drug Delivery Systems
Last Updated Date: 10/02/2012

A critical metrology issue for pharmaceutical industries is the application of analytical techniques to the characterization of drug delivery … more

Rapid Isotopic Screening
Last Updated Date: 10/02/2012

We have exploited the built-in functionality of a secondary ion mass spectrometer to provide the capability to screen the enrichment levels of a … more

Trace Narcotics Detection
Last Updated Date: 10/02/2012

A large suite of illicit drug samples were analyzed using IMS to evaluate the selectivity and sensitivity of the technique. The sample suite … more

Molecular Orbital Structure of Energetic Nitrogen Compounds from X-Ray Emission Spectroscopy
Last Updated Date: 10/02/2012

When chemical compounds of low-Z elements are excited by x-rays, the ionized core states are filled from the valence band. The molecular orbital … more

Trophic Transfer of Nanoparticles in a Simplified Invertebrate Food Web
Last Updated Date: 10/02/2012

We demonstrated that carboxylated and biotinylated quantum dots (QDs) can be transferred to higher trophic organisms (rotifers) through dietary … more

Milli X-ray Fluorescence X-ray Spectrum Imaging Technique Development
Last Updated Date: 10/02/2012

Significant improvements were made in the area of technique development for Eagle III mXRF since its initial installation in 2007. The diverse … more

Chemistry in Analytical Microscopy Group
Last Updated Date: 10/02/2012

Chemistry is the science concerned with the composition, structure, and properties of matter, as well as the changes it undergoes during chemical … more

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